Biodegradable poly(lactic acid) microspheres containing total alkaloids of Caulis sinomenii

Bulletin of Materials Science

关键词: Microsphere;    Caulis sinomenii;    PLA;    drug release;    rheumatoid arthritis.;   

学科分类：材料工程

来源: Indian Academy of Sciences

【 摘 要 】

The fabrication of biodegradable poly(lactic acid) (PLA) microspheres containing total alkaloids of Caulis sinomenii was investigated. The formation, diameter, morphology and properties of the microspheres were characterized using Fourier transform infrared spectroscopy (FT–IR), laser particle size analyser and scanning electron microscopy (SEM), etc. In vitro releasing behaviour was also investigated using UV-Vis spectrometer. As a result, the drug-loaded microspheres with a narrower distributive, rounder and smoother surface were prepared. Drug-releasing behaviour from microspheres was affected by the concentration of emulsifier and the stirring rate. The results demonstrated that a medicated system, which can be potentially applied within a drug delivery system, was designed. This system acts in a systematic manner for the treatment of rheumatoid arthritis.

【 授权许可】

CC BY