Clinical and morphological features of SARS-COV-2 associated acute hemorrhagic necrotizing encephalopathy: case report

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Victor Vladimirovich Ermilov¹  Nikita Alexeevich Dorofeev² 

[1] Department of Forensic Medicine, Volgograd State Medical University, 400131, Volgograd, Russia;Laboratory of Informatization and Digitalization of Healthcare, Volgograd Medical Research Center, 400131, Volgograd, Russia;

关键词: SARS-CoV-2;    Acute hemorrhagic necrotizing encephalopathy;    Endothelial dysfunction;    Endotheliitis;   

DOI  :  10.1186/s41983-021-00413-1

来源: Springer

【 摘 要 】

BackgroundThe current case report presents acute hemorrhagic necrotizing encephalopathy (AHNE) as an example of a fatal complication, the etiology of which could be coronavirus disease 2019 (COVID-19) with multiple organ damage along with the existing respiratory tuberculosis.Case presentationA male in his 20s had severe symptoms of central nervous system lesion, which developed against the background of COVID-19 and respiratory tuberculosis, for which he was treated in the intensive care unit. Autopsy confirmed that he died from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) associated AHNE in adults with severe fatal endothelial dysfunction and respiratory tuberculosis. The main morphological signs of brain damage were desquamative endotheliitis, thrombosis, parenchymal hemorrhagic necrosis, encephalitis, severe necrobiotic neuronal damage.ConclusionThe defeat of endothelial cells with the development of generalized endotheliitis in COVID-19, especially in conjunction with comorbid pathology, in particular tuberculosis, can lead to a fatal complication that affects the nervous system—AHNE. Therefore, it is worth paying close attention to the appearance of neurological symptoms in patients with a similar combination of diseases.

【 授权许可】

CC BY