Cytomegalovirus anterior uveitis and occlusive retinal vasculitis without retinitis in a patient on immunomodulatory therapy

Journal of Ophthalmic Inflammation and Infection

Brief Report

Laura De Benito-Llopis¹  Carlos Pavesio²  Lorenzo Fabozzi²  Ilaria Testi³ 

[1]Department of External Diseases, Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK

[2]Department of Uveitis, Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK

[3]Department of Uveitis, Moorfields Eye Hospital, National Health Service Foundation Trust, London, UK

[4]Rheumatology Department, Great Ormond Street Hospital for Children, London, UK

关键词: Cytomegalovirus virus;    Uveitis;    Endotheliitis;    Retinal vasculitis;    Retinitis;   

DOI  :  10.1186/s12348-023-00356-z

 received in 2023-06-22, accepted in 2023-07-11,  发布年份 2023

来源: Springer

【 摘 要 】

PurposeTo describe unusual clinical features and therapeutic management of a case of cytomegalovirus (CMV) ocular disease in a patient on immunomodulatory therapy.Setting/venueMoorfields Eye Hospital NHS Foundation Trust, London, UK.MethodsMedical history, clinical findings, investigation results, and multimodal imaging were retrospectively collected.ResultsA 61-year-old, South-East Asian man, developed CMV-related endotheliitis and occlusive retinal vasculitis, diagnosed by wide-angle fluorescein angiography. No retinitis was present on the fundus examination. Suspicion of CMV etiology was based on anterior segment findings, especially the presence of coin-shaped endothelial lesions. The diagnosis was confirmed by aqueous polymerase chain reaction (PCR) analysis which was positive for CMV DNA. The combined use of topical and systemic valganciclovir resulted in significant improvement of the picture.ConclusionsCMV can manifest in the eye as occlusive retinal vasculitis without the presence of typical retinitis.

【 授权许可】

CC BY   
© Springer-Verlag GmbH Germany, part of Springer Nature 2023

【 图 表 】

Fig. 4