The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to implement international neurological registries

JOURNAL OF THE NEUROLOGICAL SCIENCES

卷:414

Review

Roman, Gustavo C.^1,2  Spencer, Peter S.³  Reis, Jacques^4,5  Buguet, Alain⁶  Faris, Mostafa El Alaoui⁷  Katrak, Sarosh M.⁸  Lainez, Miguel⁹  Medina, Marco Tulio¹⁰  Meshram, Chandrashekhar¹¹  Mizusawa, Hidehiro¹²  Ozturk, Serefnur¹³  Wasay, Mohammad¹⁴ 

[1] ENSG WFN, London, England

[2] Houston Methodist Hosp, Neurol Inst, Dept Neurol, 6560 Fannin St,Suite 802, Houston, TX 77030 USA

[3] Oregon Hlth & Sci Univ, Oregon Inst Occupat Hlth Sci, Sch Med, Dept Neurol, Portland, OR 97239 USA

[4] Univ Strasbourg, F-67000 Strasbourg, France

[5] France & Assoc RISE, F-67205 Oberhausbergen, France

[6] Claude Bernard Lyon 1 Univ, Gen R French Army Hlth Serv, Malaria Res Unit, CNRS,UMR 5246, F-69622 Villeurbanne, France

[7] Mohammed V Univ Rabat, World Congress Neurol, Marrakesh WCN2011, Moroccan Fdn Neurol Dis,Neurol, Rabat, Morocco

[8] GMC & Sir JJ Grp Hosp, Jaslok Hosp & Res Ctr, Dept Neurol, Mumbai, Maharashtra, India

[9] Catholic Univ Valencia, Univ Clin Hosp, Dept Neurol, Spanish Neurol Soc, Valencia 46010, Spain

[10] Natl Autonomous Univ Honduras, Fac Med Sci, Neurol & Epileptol, Latin Amer,WFN,Pan Amer Federat Neurol Soc PAFNS, Tegucigalpa, Honduras

[11] Indian Acad Neurol, Nagpur, Maharashtra, India

[12] Grad Sch Med & Dent Sci, Dept Neurol & Neurol Sci, NCNP, World Congress Neurol,Kyoto WCN2017, Tokyo, Japan

[13] Selcuk Univ, Fac Med, Dept Neurol, Turkish Neurol Soc, Konya, Turkey

[14] Aga Khan Univ, Neurol, Pakistan Int Neurosci Soc, Karachi, Pakistan

关键词: Coronaviruses;    Coronavirus disease 2019;    COVID-19 neurological complications;    Endotheliitis;    Environmental neurology;    MERS;    MERS-CoV;    Neuroepidemiology;    Neuropathology;    Pandemic;    SARS;    SARS-CoV-1;    SARS-CoV-2;    Viral neurotropism;    Zoonosis;   

DOI  :  10.1016/j.jns.2020.116884

来源: Elsevier

【 摘 要 】

A comprehensive review of the neurological disorders reported during the current COVID-19 pandemic demonstrates that infection with SARS-CoV-2 affects the central nervous system (CNS), the peripheral nervous system (PNS) and the muscle. CNS manifestations include: headache and decreased responsiveness considered initial indicators of potential neurological involvement; anosmia, hyposmia, hypogeusia, and dysgeusia are frequent early symptoms of coronavirus infection. Respiratory failure, the lethal manifestation of COVID-19, responsible for 264,679 deaths worldwide, is probably neurogenic in origin and may result from the viral invasion of cranial nerve I, progressing into rhinencephalon and brainstem respiratory centers. Cerebrovascular disease, in particular large-vessel ischemic strokes, and less frequently cerebral venous thrombosis, intracerebral hemorrhage and subarachnoid hemorrhage, usually occur as part of a thrombotic state induced by viral attachment to ACE2 receptors in endothelium causing widespread endotheliitis, coagulopathy, arterial and venous thromboses. Acute hemorrhagic necrotizing encephalopathy is associated to the cytokine storm. A frontal hypoperfusion syndrome has been identified. There are isolated reports of seizures, encephalopathy, meningitis, encephalitis, and myelitis. The neurological diseases affecting the PNS and muscle in COVID-19 are less frequent and include Guillain-Barre syndrome; Miller Fisher syndrome; polyneuritis cranialis; and rare instances of viral myopathy with rhabdomyolysis. The main conclusion of this review is the pressing need to define the neurology of COVID-19, its frequency, manifestations, neuropathology and pathogenesis. On behalf of the World Federation of Neurology we invite national and regional neurological associations to create local databases to report cases with neurological manifestations observed during the on-going pandemic. International neuroepidemiological collaboration may help define the natural history of this worldwide problem.

【 授权许可】

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