New Delhi metallo-β-lactamase-1 among Escherichia coli strains isolated from leukemia patients in Iran: two case reports

Journal of Medical Case Reports

Alireza Goodarzi¹  Mahdane Roshani²  Mohammad Reza Arabestani²  Sanaz Dehbashi²  Farhad Afrasiabi²  Ali Hashemi³  Hossein Goudarzi³ 

[1] Department of Medical Laboratory Sciences, School of Paramedicine, Hamadan University of Medical Sciences, Shahid Fahmideh Street, Park Mardome, Hamadan, IR, Iran;Department of Microbiology, Faculty of Medicine, Nutrition Research Center, Hamadan University of Medical Sciences, Shahid Fahmideh Street, Park Mardome, Hamadan, IR, Iran;Department of Microbiology, Shahid Beheshti University of Medical Sciences, Shahid Shahriari Square, Daneshjou Boulevard, Shahid Chamran Highway, 1983969411, Tehran, Iran;

关键词: bla;    Escherichia coli;    Klebsiella pneumoniae;    Leukemia;   

DOI  :  10.1186/s13256-021-03160-2

来源: Springer

【 摘 要 】

BackgroundEscherichia coli has appeared as an important opportunistic pathogen responsible for nosocomial infections in patients with immunodeficiency, particularly in leukemia patients. New Delhi metallo-beta-lactamase is an enzyme originally found in Enterobacteriaceae.Case presentationIn this study, 80 isolates of Escherichia coli and Klebsiella pneumoniae were collected over the course of 2 years from two medical centers in Tehran, Iran. Production of carbapenemase was detected in the isolates using modified Hodge test. New Delhi metallo-beta-lactamase-1 genes were detected by polymerase chain reaction amplification with specific primers. Two New Delhi metallo-beta-lactamase-1-producing Escherichia coli strains were isolated from two Iranian patients with leukemia. These two patients were 6 and 15 years old, one female and the other male, from two oncology centers in Iran. The isolates were resistant to carbapenems (imipenem, meropenem), and two isolates were positive for carbapenemase production by modified Hodge test.ConclusionsThe emergence of New Delhi metallo-beta-lactamase-1-producing Escherichia coli is a threat for leukemia patients in oncology and hematology departments. We conclude that the incidence of multidrug resistant pathogens has increased among patients with leukemia and is life threatening.

【 授权许可】

CC BY