Fibroblast growth factor 21 associating with serotonin and dopamine in the cerebrospinal fluid predicts impulsivity in healthy subjects

BMC Neuroscience

Fan Wang¹  Wenhui Lin²  Yuncao Fan²  Jinzhong Xu³  Fenzan Wu⁴  Xiaokun Li⁵  Yuying Li⁵  Lijing Chen⁶  Huai Li⁶  Haiyun Xu⁷  Li Chen⁷  Yanlong Liu⁷  Jue He⁸  Song Qian⁹  Hui Li^1,10 

[1] Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China;Key Laboratory of Psychosomatic Medicine, Inner Mongolia Medical University, Huhhot, China;Central Laboratory, Affiliated Wenling Hospital, Wenzhou Medical University, Wenling, Zhejiang, China;Department of Clinical Pharmacy, Affiliated Wenling Hospital, Wenzhou Medical University, Wenling, Zhejiang, China;Laboratory of Translational Medicine, Affiliated Cixi Hospital, Wenzhou Medical University, Ningbo, Zhejiang, China;School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China;The Affiliated Kangning Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China;School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang, China;The Affiliated Kangning Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China;School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang, China;Institute of Aging, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China;The Affiliated Kangning Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China;School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang, China;Institute of Aging, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China;Institute of Neurological Disease, First Affiliated Hospital, Henan University, Kaifeng, Henan, China;The Criminal Science and Technology Department, Zhejiang Police College, Hangzhou, Zhejiang, China;Xinjiang Key Laboratory of Neurological Disorder Research, the Second Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China;

关键词: Impulsivity;    FGF21;    Serotonin;    Dopamine;    Cerebrospinal fluid;    Mental disorders;   

DOI  :  10.1186/s12868-021-00676-7

来源: Springer

【 摘 要 】

BackgroundImpulsivity is more commonly reported in subjects with mental disorders compared to healthy subjects, suggesting a potential application of impulsivity in predicting impulsivity-related mental disorders. However, no biomarker of impulsivity available so far. This study explored the association between cerebrospinal fluid (CSF) fibroblast growth factor 21 (FGF21), a key hormonal mediator of the stress response, and impulsivity in healthy subjects.MethodsA total of 126 healthy persons subjected to surgery of anterior cruciate ligament were recruited in the present study. The impulsiveness of the subjects was evaluated by the Chinese version of the Barratt Impulsiveness Scale (BIS)-11 before surgery. CSF and blood samples of the subjects were collected before spinal anesthesia for surgery. The levels of FGF21, serotonin and dopamine in CSF and the level of FGF21 in blood of the subjects were measured by ELISA using commercial kits.ResultsNegative correlations were found between BIS-11 total score and either FGF21, serotonin or dopamine in CSF. However, BIS-11 total score was not correlated with FGF21 in blood. In addition, FGF21 was positively correlated with serotonin and dopamine in CSF, respectively. Multivariable linear regression models indicated that the decrease of FGF21 level associating with the decrease of serotonin and dopamine level in CSF contributed to the higher impulsivity. Furthermore, receiver operating characteristic curve (ROC) analysis indicated an important role of CSF FGF21 predicting high impulsivity.ConclusionsFGF21, serotonin and dopamine in CSF associate with impulsivity in opposite directions. The decrease of CSF FGF21 is related to higher impulsivity, and indicate that CSF FGF21 may predict impulsivity in healthy subjects.

【 授权许可】

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