Functional imaging studies of Impulse Control Disorders in Parkinson's disease need a stronger neurocognitive footing

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

卷:98

Review

Meyer, Garance M.¹  Spay, Charlotte¹  Laurencin, Chloe^2,3  Ballanger, Benedicte²  Sescousse, Guillaume⁴  Boulinguez, Philippe¹ 

[1] Univ Claude Bernard Lyon 1, Univ Lyon, Act Control & Related Disorders Team, Lyon Neurosci Res Ctr,CNRS,UMR 5292,INSERM,U1028, F-69000 Lyon, France

[2] Univ Claude Bernard Lyon 1, Univ Lyon, Neuroplast & Neuropathol Olfactory Percept team, Lyon Neurosci Res Ctr,CNRS,UMR 5292,INSERM,U1028, F-69000 Lyon, France

[3] Hosp Civils Lyon, Hop Neurol Pierre, Ctr Expert Parkinson, Serv Neurol C, Lyon, France

[4] Univ Claude Bernard Lyon 1, Univ Lyon, Lyon Neurosci Res Ctr, CNRS,UMR 5292,INSERM,U1028,PsyR2 Team, F-69000 Lyon, France

关键词: Impulsivity;    Parkinson's disease;    fMRI;    PET;    Dopamine;    Noradrenaline;    Serotonin;   

DOI  :  10.1016/j.neubiorev.2019.01.008

来源: Elsevier

【 摘 要 】

Impulse control disorders (ICDs) in Parkinson's disease (PD) are associated with dopaminergic dysfunction and treatment, but have no satisfactory therapeutic solution. While studies assessing the neurofunctional bases of ICDs are important for advancing our understanding and management of ICDs, they remain sparse and inconsistent. Based on a systematic analysis of the neuroimaging literature, the present review pinpoints various abnormalities beyond the mesocorticolimbic circuit that supports reward processing, suggesting possible dysfunction at the sensorimotor, executive and affective levels. We advocate that: 1) Future studies should use more sophisticated psychological models and behavioral designs that take into account the potentially multifaceted aspect of ICDs; this would allow a more accurate assessment of the underlying neurocognitive processes, which are not all dependent on the dopaminergic system. 2) Future neuroimaging studies should rely more strongly on task-based, event-related analyses to disentangle the various mechanisms that can be dysfunctional in ICDs. We believe these guidelines constitute a prerequisite towards distinguishing causes, correlates and individual susceptibility factors of PD patients with ICDs.

【 授权许可】

Free