The short (S) allele of the serotonin transporter polymorphism and acute tryptophan depletion both increase impulsivity in men

NEUROSCIENCE LETTERS

卷:473

Article

Walderhaug, Espen^1,5  Magnusson, Andres²  Morgan, Michael John^3,4  Landro, Nils Inge⁵ 

[1] Yale Univ, Sch Med, Dept Psychiat, West Haven, CT 06516 USA

[2] Natl Univ Hosp Reykjavik, Dept Psychiat, Reykjavik, Iceland

[3] Univ Sussex, Dept Psychol, Brighton BN1 9RH, E Sussex, England

[4] Univ Oslo, Norwegian Ctr Addict Res, N-0316 Oslo, Norway

[5] Univ Oslo, Dept Psychol, Ctr Study Human Cognit, N-0316 Oslo, Norway

关键词: Serotonin;    5-HTTLPR;    Genetics;    Impulsivity;    Signal detection theory;    Tryptophan depletion;   

DOI  :  10.1016/j.neulet.2010.02.048

来源: Elsevier

【 摘 要 】

Reduced serotonergic neurotransmission is implicated in impulsive behavior. We studied the triallelic system of the serotonin transporter gene linked polymorphic region (5-HTTLPR) and acute manipulation of serotonin together to further delineate the mechanisms by which serotonergic neurotransmission affects impulsivity. Fifty-two healthy participants (38 men and 14 women) underwent acute tryptophan depletion (ATD) or placebo in a randomized, double-blind, parallel group experiment. Impulsive response style was measured on two versions of the Continuous Performance Task (CPT), and calculated using signal detection theory. We observed a dose-dependent effect for the short (S') allele of the 5-HTTLPR on impulsive response style. Individuals who had the S'/S' genotype were more impulsive than individuals with the L/S' genotype. Participants with the L/S' genotype were more impulsive than those with the L/L genotype. ATD increased impulsivity in men, and decreased impulsivity in women. These data demonstrate for the first time that reduced serotonergic tone as a result of either 5-HTTLPR genotype, or experimental AID, are both independently and additively, associated with elevated impulsive response style in Caucasian men. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

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