Childhood maltreatment, serotonin transporter gene, and risk for callous and unemotional traits: A prospective investigation

PSYCHIATRY RESEARCH

卷:291

Article

Widom, Cathy Spatz^1,2  Miller, Dana¹  Li, Xuechen¹  Gordon, Derek^3,4  Brzustowicz, Linda^3,4 

[1] CUNY, John Jay Coll, Psychol Dept, 524W 59th St, New York, NY 10019 USA

[2] CUNY, Grad Ctr, 524W 59th St, New York, NY 10019 USA

[3] Rutgers State Univ, Dept Genet, 145 Bevier Rd, Piscataway, NJ 08854 USA

[4] Rutgers State Univ, Human Genet Inst, 145 Bevier Rd, Piscataway, NJ 08854 USA

关键词: Child maltreatment;    Abuse/neglect;    Serotonin;    Callous/unemotional traits;    5-HTTLPR;    Prospective cohort design;   

DOI  :  10.1016/j.psychres.2020.113271

来源: Elsevier

【 摘 要 】

Previous studies have reported associations between the serotonin transporter 5-HTTLPR genotype and antisocial and aggressive traits and between child maltreatment and antisocial traits. However, few studies have examined whether 5-HTTLPR moderates the influence of childhood maltreatment on callous and unemotional traits, a hallmark of psychopathy. Using a prospective cohort design, children with documented cases of maltreatment and matched controls were followed up and interviewed in adulthood. DNA was extracted from blood and saliva (N = 414) and callous-unemotional (CU) traits were assessed. Childhood maltreatment predicted higher CU scores in adulthood, whereas the effect of 5-HTTLPR was not significant. The effect of child maltreatment on CU traits did not differ by genetic risk (high or low activity 5-HTTLPR), whereas controls with the LL genotype had higher CU scores than controls with the SS genotype. Similar results were found for females and White, non-Hispanics, but not for males and Blacks. Variations in 5-HTTLPR did not affect the impact of child maltreatment on CU traits in adulthood. Genetic risk had a stronger effect on adults with lower environmental risk (controls). Having a history of child maltreatment or the LL genotype placed participants at risk for higher levels of callous and unemotional trait scores.

【 授权许可】

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