MRI-based radiomics and ADC values are related to recurrence of endometrial carcinoma: a preliminary analysis

BMC Cancer

Yu Zhang¹  Kaiyue Zhang¹  Liting Qian²  Jiangning Dong³  Xin Fang⁴ 

[1] Department of Radiation Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical University, 230001, Hefei, China;Department of Radiation Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical University, 230001, Hefei, China;Department of Radiation Oncology, First Affiliated Hospital of University of Science and Technology of China, 230001, Hefei, China;Department of Radiation Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical University, 230001, Hefei, China;Department of Radiology, First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Cancer Hospital, 230031, Hefei, China;Department of Radiology, First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Cancer Hospital, 230031, Hefei, China;

关键词: Endometrial neoplasms;    Recurrence;    Risk factors;    Apparent diffusion coefficient;    Radiomics;   

DOI  :  10.1186/s12885-021-08988-x

来源: Springer

【 摘 要 】

BackgroundTo identify predictive value of apparent diffusion coefficient (ADC) values and magnetic resonance imaging (MRI)-based radiomics for all recurrences in patients with endometrial carcinoma (EC).MethodsOne hundred and seventy-four EC patients who were treated with operation and followed up in our institution were retrospectively reviewed, and the patients were divided into training and test group. Baseline clinicopathological features and mean ADC (ADCmean), minimum ADC (ADCmin), and maximum ADC (ADCmax) were analyzed. Radiomic parameters were extracted on T2 weighted images and screened by logistic regression, and then a radiomics signature was developed to calculate the radiomic score (radscore). In training group, Kaplan–Meier analysis was performed and a Cox regression model was used to evaluate the correlation between clinicopathological features, ADC values and radscore with recurrence, and verified in the test group.ResultsADCmean showed inverse correlation with recurrence, while radscore was positively associated with recurrence. In univariate analyses, FIGO stage, pathological types, myometrial invasion, ADCmean, ADCmin and radscore were associated with recurrence. In the training group, multivariate Cox analysis showed that pathological types, ADCmean and radscore were independent risk factors for recurrence, which were verified in the test group.ConclusionsADCmean value and radscore were independent predictors of recurrence of EC, which can supplement prognostic information in addition to clinicopathological information and provide basis for individualized treatment and follow-up plan.

【 授权许可】

CC BY