Effects of a Brazilian cardioprotective diet and nuts on cardiometabolic parameters after myocardial infarction: study protocol for a randomized controlled clinical trial

Trials

Malaine Morais Alves Machado¹  Ana Paula Perillo Ferreira Carvalho¹  Francisca Eugenia Zaina Nagano²  José Albuquerque de Figueiredo Neto³  Luciana Pereira Pinto Dias³  Graziela Biude Silva Duarte⁴  Eduardo Purgatto⁵  Elizabeth Aparecida Ferraz da Silva Torres⁶  Geni Rodrigues Sampaio⁶  Marcelo Macedo Rogero⁶  Ana Paula Trussardi Fayh⁷  Leopoldo Piegas⁸  Gabriela Corrêa Souza⁹  Danielle Soares Bezerra^1,10  Jéssika Araújo^1,11  Sandra Mary Lima Vasconcelos^1,11  Alexandre Schaan de Quadros^1,12  Camila Weschenfelder^1,12  Júlia Lorenzon dos Santos^1,12  Camila Ragne Torreglosa^1,13  Angela Cristine Bersch-Ferreira^1,13  Erica Regina Ribeiro Sady^1,13  Lucas Ribeiro da Silva^1,13  Rosana Perim Costa^1,13  Bernardete Weber^1,13  Rachel Helena Vieira Machado^1,13  Alexandre Biasi Cavalcanti^1,13  Debora Harumi Kodama Miyada^1,13  Renato Hideo Nakagawa Santos^1,13  Erlon Oliveira de Abreu-Silva^1,14  Aline Marcadenti^1,15  Enilda Maria de Sousa Lara^1,16  Annie Seixas Bello Moreira^1,17  Débora Pinto Gapanowicz^1,17  Suena Medeiros Parahiba^1,18  Cássia Cristina Paes de Almeida^1,19 

[1] Clinical Nutrition Unit, Hospital de Clínicas, Universidade Federal de Goiás (HC-UFG/EBSERH), Goiânia, Goiás, Brazil;Complexo Hospital de Clínicas da Universidade Federal do Paraná (HC-UFPR), Curitiba, Paraná, Brazil;Department of Cardiology, Universidade Federal do Maranhão (UFMA), São Luiz, Maranhão, Brazil;Department of Food Science and Experimental Nutrition, Faculty of Pharmaceutical Science, Universidade de São Paulo (USP), São Paulo, São Paulo, Brazil;Department of Food Science and Experimental Nutrition/Food Research Center, Faculty of Pharmaceutical Sciences, Universidade de São Paulo (USP), São Paulo, São Paulo, Brazil;Department of Nutrition, School of Public Health, Universidade de São Paulo (USP), São Paulo, São Paulo, Brazil;Department of Nutrition, Universidade Federal do Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil;Division of Cardiology, Hospital do Coração (HCor), São Paulo, São Paulo, Brazil;Division of Nutrition, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil;Post-Graduation Program in Food, Nutrition and Health, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil;Faculty of Health Science of Trairi, Universidade Federal do Rio Grande do Norte (FACISA-UFRN), Santa Cruz, Rio Grande do Norte, Brazil;Faculty of Nutrition, Universidade Federal de Alagoas (UFAL), Maceió, Alagoas, Brazil;Graduate Program in Health Sciences (Cardiology), Instituto de Cardiologia/Fundação Universitária de Cardiologia (IC/FUC), Porto Alegre, Rio Grande do Sul, Brazil;HCor Research Institute (IP-HCor), Hospital do Coração (HCor), Abílio Soares Street, 250, 12th floor, Zip Code 04004-050, São Paulo, SP, Brazil;HCor Research Institute (IP-HCor), Hospital do Coração (HCor), Abílio Soares Street, 250, 12th floor, Zip Code 04004-050, São Paulo, SP, Brazil;Division of Cardiology, Hospital do Coração (HCor), São Paulo, São Paulo, Brazil;Hemodynamics Service, Hospital do Servidor Público Estadual (HSPE), São Paulo, São Paulo, Brazil;HCor Research Institute (IP-HCor), Hospital do Coração (HCor), Abílio Soares Street, 250, 12th floor, Zip Code 04004-050, São Paulo, SP, Brazil;Graduate Program in Health Sciences (Cardiology), Instituto de Cardiologia/Fundação Universitária de Cardiologia (IC/FUC), Porto Alegre, Rio Grande do Sul, Brazil;Health Knowledge Implementation Laboratory (LICS), Hospital do Coração (HCor), São Paulo, São Paulo, Brazil;Instituto Nacional de Cardiologia (INC), Rio de Janeiro, Rio de Janeiro, Brazil;Post-Graduation Program in Food, Nutrition and Health, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil;Universidade Federal do Paraná (UFPR), Curitiba, Paraná, Brazil;

关键词: Myocardial infarction;    Nuts;    Atherosclerosis;    Secondary prevention;    Diet, Healthy;    Arachis;    Bertholletia;    Anacardium;   

DOI  :  10.1186/s13063-021-05494-0

来源: Springer

【 摘 要 】

BackgroundNut consumption has been related to improvements on cardiometabolic parameters and reduction in the severity of atherosclerosis mainly in primary cardiovascular prevention. The objective of this trial is to evaluate the effects of the Brazilian Cardioprotective Diet (DIetaCArdioprotetoraBrasileira, DICA Br) based on consumption of inexpensive locally accessible foods supplemented or not with mixed nuts on cardiometabolic features in patients with previous myocardial infarction (MI).MethodsDICA-NUTS study is a national, multicenter, randomized 16-week follow-up clinical trial. Patients over 40 years old with diagnosis of previous MI in the last 2 to 6 months will be recruited (n = 388). A standardized questionnaire will be applied to data collection and blood samples will be obtained. Patients will be allocated in two groups: Group 1: DICA Br supplemented with 30 g/day of mixed nuts (10 g of peanuts, 10 g of cashew, 10 g of Brazil nuts); and Group 2: only DICA Br. The primary outcome will consist of LDL cholesterol means (in mg/dL) after 16 weeks of intervention. Secondary outcomes will consist of other markers of lipid profile, glycemic profile, and anthropometric data.DiscussionIt is expected that DICA Br supplemented with mixed nuts have superior beneficial effects on cardiometabolic parameters in patients after a MI, when compared to DICA Br.Trial registrationClinicalTrials.gov Identifier NCT03728127. First register: November 1, 2018; Last update: June 16, 2021. World Health Organization Universal Trial Number (WHO-UTN): U1111-1259-8105.

【 授权许可】

CC BY