MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies

Journal of Hematology & Oncology

Seyed Esmaeil Ahmadi¹  Bahman Zarandi¹  Samira Rahimi¹  Majid Safa²  Rouzbeh Chegeni³ 

[1] Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran;Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran;Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran;Medical Laboratory Sciences Program, College of Health and Human Sciences, Northern Illinois University, DeKalb, IL, USA;

关键词: MYC;    Oncogene;    Regulation;    Cell cycle;    Apoptosis;    DNA damage response;    Prognostic importance;    Therapeutic implications;    Hematological malignancies;   

DOI  :  10.1186/s13045-021-01111-4

来源: Springer

【 摘 要 】

MYC oncogene is a transcription factor with a wide array of functions affecting cellular activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to the multi-functionality of MYC, its expression is regulated at multiple levels. Deregulation of this oncogene can give rise to a variety of cancers. In this review, MYC regulation and the mechanisms by which MYC adjusts cellular functions and its implication in hematologic malignancies are summarized. Further, we also discuss potential inhibitors of MYC that could be beneficial for treating hematologic malignancies.

【 授权许可】

CC BY