Making decisions through Myc

FEBS Letters

Rosati, Jessica¹  Ciarapica, Roberta¹  Nasi, Sergio¹  Soucek, Laura¹  Jucker, Richard¹ 

[1] Centro Acidi Nucleici CNR, Dipartimento di Genetica e Biologia Molecolare, Università La Sapienza, P.le A. Moro 5, 00185 Rome, Italy

关键词: Oncogene;    G1;    Cell cycle;    Transcription;    Repression;    Chromatin modelling;   

DOI  :  10.1016/S0014-5793(01)02118-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

c-Myc is a transcriptional regulator involved in carcinogenesis through its role in growth control and cell cycle progression. Here we attempt to relate its role in stimulating the G1–S transition to the ability to affect functioning of key cell cycle regulators, and we focus on how its property of modulating transcription of a wide range of target genes could explain its capacity to affect multiple pathways leading to proliferation, apoptosis, growth, and transformation.

【 授权许可】

Unknown