SARS-CoV-2/DENV co-infection: a series of cases from the Federal District, Midwestern Brazil

BMC Infectious Diseases

Ana Paula Monteiro Gomides Reis¹  Marcus Vinicius Guimarães Lacerda²  José Diego Brito-Sousa³  Clara Correia de Siracusa⁴  Luciana Ansaneli Naves⁴  Selma Regina Penha Silva Cerqueira⁴  Mariana Sirimarco Fernandes⁵  Laila Salmen Espindola⁶  Heidi Luise Schulte⁶  Eliana Teles de Gois⁷  Valéria Paes Lima⁸  Carlos Henrique Reis Esselin Rassi⁸  Licia Maria Henrique da Mota⁹  Cleandro Pires de Albuquerque⁹  Lizandra Moura Paravidine Sasaki⁹  Patricia Shu Kurizky⁹  Ciro Martins Gomes^1,10 

[1] Faculdade de Medicina, UNICEUB, Brasília, Brazil;Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil;Instituto Leônidas & Maria Deane, Fundação Oswaldo Cruz, Manaus, Brazil;Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil;Universidade do Estado do Amazonas, Manaus, Brazil;Hospital Universitário de Brasília, Brasília, Brazil;Hospital Universitário de Brasília, Brasília, Brazil;Corpo Bombeiros Militar do Distrito Federal, Brasília, Brazil;Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade de Brasília – UnB, Brasília, Brazil;Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade de Brasília – UnB, Brasília, Brazil;Hospital Regional do Gama, Secretaria de Estado de Saúde do Distrito Federal, Brasília, Brazil;Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade de Brasília – UnB, Brasília, Brazil;Hospital Sírio Libanês de Brasília, Brasília, Brazil;Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade de Brasília – UnB, Brasília, Brazil;Hospital Universitário de Brasília, Brasília, Brazil;Programa de Pós-Graduação em Ciências Médicas, Faculdade de Medicina, Universidade de Brasília – UnB, Brasília, Brazil;Hospital Universitário de Brasília, Brasília, Brazil;Programa de Pós-Graduação em Medicina Tropical, Faculdade de Medicina, Universidade de Brasília – UnB, Brasília, Brazil;

关键词: COVID-19;    Dengue;    SARS-CoV-2;    DENV;    Co-infection;    Case series;   

DOI  :  10.1186/s12879-021-06456-2

来源: Springer

【 摘 要 】

BackgroundSince the novel coronavirus disease outbreak, over 179.7 million people have been infected by SARS-CoV-2 worldwide, including the population living in dengue-endemic regions, particularly Latin America and Southeast Asia, raising concern about the impact of possible co-infections.MethodsThirteen SARS-CoV-2/DENV co-infection cases reported in Midwestern Brazil between April and September of 2020 are described. Information was gathered from hospital medical records regarding the most relevant clinical and laboratory findings, diagnostic process, therapeutic interventions, together with clinician-assessed outcomes and follow-up.ResultsOf the 13 cases, seven patients presented Acute Undifferentiated Febrile Syndrome and six had pre-existing co-morbidities, such as diabetes, hypertension and hypopituitarism. Two patients were pregnant. The most common symptoms and clinical signs reported at first evaluation were myalgia, fever and dyspnea. In six cases, the initial diagnosis was dengue fever, which delayed the diagnosis of concomitant infections. The most frequently applied therapeutic interventions were antibiotics and analgesics. In total, four patients were hospitalized. None of them were transferred to the intensive care unit or died. Clinical improvement was verified in all patients after a maximum of 21 days.ConclusionsThe cases reported here highlight the challenges in differential diagnosis and the importance of considering concomitant infections, especially to improve clinical management and possible prevention measures. Failure to consider a SARS-CoV-2/DENV co-infection may impact both individual and community levels, especially in endemic areas.

【 授权许可】

CC BY