SARS-CoV-2 and dengue virus coinfection in an adult with beta-thalassemia (trait): A case report from Bangladesh with literature review

Heliyon

Zannatun Nyma¹  Monira Sarmin²  Tahmeed Ahmed³  Lubaba Shahrin⁴  Hafizur Rahman⁵  Mohammod Jobayer Chisti⁵  Md Rezaul Hossain⁵ 

[1] Cancer Biology, Laboratory Sciences &Corresponding author.;Services Division (LSSD), icddr,b;;Clinical Hematology &Nutrition and Clinical Services Division (NCSD), icddr,b;

关键词: COVID-19;    SARS-CoV-2;    Dengue;    Beta-thalassemia;    Hemoglobinopathies;    Bangladesh;   

DOI  :  

来源: DOAJ

【 摘 要 】

Introduction: Coinfections are common in pandemics, however not in recorded patients with hemoglobinopathies. The Coronavirus Disease 2019 (COVID-19) pandemic struck Bangladesh at the beginning of March 2020, which is also an apt period for endemic Dengue fever in this monsoon region. Case report: We report a 30-year-old man with hemoglobinopathies coinfected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Dengue virus. Dengue virus was detected by Enzyme-linked Immunosorbent Assay (ELISA). COVID-19 was confirmed by Reverse-transcription Polymerase Chain Reaction (RT-PCR) and Hemoglobin Electrophoresis revealed heterozygous beta-thalassemia or thalassemia trait. The patient was treated successfully at Dhaka Hospital in icddr,b during COVID-19 emergency response with symptomatic supportive treatment for COVID-19 and appropriate fluid therapy for dengue fever in response to daily hematocrit level. The patient's repeated RT-PCR for COVID-19 on day-21 became negative. For thalassemia, the patient was advised to have genetic counseling and family screening on discharge. Conclusion: The possibility of coinfection between COVID-19 and Dengue fever may be considered in a COVID-19 patient with unremitting fever especially in an area where Dengue fever is epidemic that may further help to attain appropriate management of the patient.

【 授权许可】

Unknown