Revista Brasileira de Otorrinolaringologia | |
The role of CSE1L expression in cervical lymph node metastasis of larynx tumors | |
article | |
Tuncay Tunccan1  Sertac Duzer2  Gulay Dilek3  Ulvi Murat Yuksel4  Hasan Cetiner2  Caner Kılıc1  Ayca Ant1  Arzu Betul Duran1  | |
[1] Oncology Training and Research Hospital, Department of Ear Nose and Throat;Elazig Training and Research Hospital, Department of Ear Nose and Throat;Oncology Training and Research Hospital, Department of Pathology;Oncology Training and Research Hospital, Department of Surgery | |
关键词: T3---T4 glottic cancer; CSE1L; Lymph node; Metastasis; | |
DOI : 10.1016/j.bjorl.2019.06.010 | |
学科分类:医学(综合) | |
来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial | |
【 摘 要 】
Introduction: According to international reports, 30---40% of all head and neck cancers are larynx cancers, comprising 1---2.5% of all cancer types. Cervical nodal involvement has been reported to be 40% and 65% in T3 and T4 cases, respectively. Five-year survival in patients with cervical lymph node metastasis has been demonstrated to be 50% lower compared to patients with no metastasis. Chromosome segregation like 1 protein; is a DNA fragment isolated by Brinkmann et al. in 1995 that corresponds to yeast chromosome segregation protein. Studies on the effect of chromosome segregation like 1 protein expression in head and neck tumors are rare and it has been shown that nuclear chromosome segregation like 1 protein is over-expressed in these studies where gastrointestinal and breasttumors over-expressed cytoplasmic chromosome segregation like 1 protein. Objective: Chromosome segregation like 1 protein may regulate the proliferation and metastasis of T3---T4 glottic larynx cancer. The aim of this study is to show the relationship between chromosome segregation like 1 protein expression and cervical lymph node metastasis of T3---T4 glottic larynx cancer. Methods: A total of 57 male patients who were operated for T3---T4 glottic cancer in a tertiary referral hospital was included in this study. There were 28 patients with cervical lymph node metastasis and 29 patients without lymph node metastasis. Immunohistochemistry was carried out on formalin-fixed, paraffin-embedded archival glottic larynx tumour tissue. According to the percentage of immunoreactive cells, chromosome segregation like 1 protein status was analyzed.
【 授权许可】
CC BY
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