The role of CSE1L expression in cervical lymph node metastasis of larynx tumors

Revista Brasileira de Otorrinolaringologia

article

Tuncay Tunccan¹  Sertac Duzer²  Gulay Dilek³  Ulvi Murat Yuksel⁴  Hasan Cetiner²  Caner Kılıc¹  Ayca Ant¹  Arzu Betul Duran¹ 

[1] Oncology Training and Research Hospital, Department of Ear Nose and Throat;Elazig Training and Research Hospital, Department of Ear Nose and Throat;Oncology Training and Research Hospital, Department of Pathology;Oncology Training and Research Hospital, Department of Surgery

关键词: T3---T4 glottic cancer;    CSE1L;    Lymph node;    Metastasis;   

DOI  :  10.1016/j.bjorl.2019.06.010

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

Introduction: According to international reports, 30---40% of all head and neck cancers are larynx cancers, comprising 1---2.5% of all cancer types. Cervical nodal involvement has been reported to be 40% and 65% in T3 and T4 cases, respectively. Five-year survival in patients with cervical lymph node metastasis has been demonstrated to be 50% lower compared to patients with no metastasis. Chromosome segregation like 1 protein; is a DNA fragment isolated by Brinkmann et al. in 1995 that corresponds to yeast chromosome segregation protein. Studies on the effect of chromosome segregation like 1 protein expression in head and neck tumors are rare and it has been shown that nuclear chromosome segregation like 1 protein is over-expressed in these studies where gastrointestinal and breasttumors over-expressed cytoplasmic chromosome segregation like 1 protein. Objective: Chromosome segregation like 1 protein may regulate the proliferation and metastasis of T3---T4 glottic larynx cancer. The aim of this study is to show the relationship between chromosome segregation like 1 protein expression and cervical lymph node metastasis of T3---T4 glottic larynx cancer. Methods: A total of 57 male patients who were operated for T3---T4 glottic cancer in a tertiary referral hospital was included in this study. There were 28 patients with cervical lymph node metastasis and 29 patients without lymph node metastasis. Immunohistochemistry was carried out on formalin-fixed, paraffin-embedded archival glottic larynx tumour tissue. According to the percentage of immunoreactive cells, chromosome segregation like 1 protein status was analyzed.

【 授权许可】

CC BY