The Study of 99mTc-Aluminum Oxide Using for Sentinel Lymph Nodes Detection in Experiment

8th International Scientific Conference "Issues of Physics and Technology in Science, Industry and Medicine"

物理学;工业技术;医药卫生

Medvedeva, A.A.^1,2 ; Sinilkin, I.G.^1,2 ; Zelchan, R.V.^1,2 ; Chernov, V.I.^1,2 ; Lyapunov, A.Yu.^1 ; Bragina, O.D.^2 ; Varlamova, N.V.^2 ; Skuridin, V.S.^2 ; Dergilev, A.P.^3

Tomsk Cancer Research Institute, Kooperativny Street 5, Tomsk, Russia^1

Tomsk Polytechnic University, Lenin Avenue 30, Tomsk, Russia^2

Novosibirsk State Medical University, Krasny Prospect 52, Novosibirsk, Russia^3

关键词: Colloidal particle;    Comparative research;    Inguinal lymph nodes;    Intra-operative;    Lymph node;    Lymphatic systems;    Sentinel lymph nodes;    Sol particles;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/135/1/012027/pdf
DOI  :  10.1088/1757-899X/135/1/012027

来源: IOP

【 摘 要 】

The purpose of the study was a comparative research of the possibility of using the radiopharmaceuticals99mTc-Al2O3and99mTc-Nanocis for visualizing sentinel lymph nodes in the experiment. Measurement of the sizes of99mTc-Al2O3and99mTc-Nanocis colloidal particles was performed in seven series of radiopharmaceuticals. Pharmacokinetics of99mTc-Al2O3and99mTc-Nanocis was researched on 50 white male rats. The possibility of the use of99mTc-Al2O3and99mTc-Nanocis for lymphoscintigraphy was studied in the experiments on 12 white male rats. Average dynamic diameter of the sol particle was 52-77 nm for99mTc-Al2O3and 16.7-24.5 nm for99mTc-Nanocis. Radiopharmaceuticals accumulated in the inguinal lymph node - at 1 hour after administration the average uptake of99mTc-Al2O3was 8.6% in it and the accumulation of99mTc-Nanocis was significantly lower - 1,8% (p 99mTc-Al2O3in the lymph node was significantly higher99mTc-Nanocis accumulation. The results dynamic scintigraphic studies in rats showed that99mTc-Al2O3and99mTc-Nanocis actively accumulated into the lymphatic system. By using99mTc-Al2O3inguinal lymph node was determined in 5 minutes after injection and clearly visualize in all the animals in the 15th minute, when the accumulation became more than 1% of the administered dose. Further observation indicated that the99mTc-Al2O3accumulation reaches a plateau in a lymph node (average 10.5%) for 2 hour study and then its accumulation remains practically at the same level, slightly increasing to 12% at 24 hours. In the case of99mTc-Nanocis inguinal lymph node visualized in all animals for 15 minutes when it was accumulated on the average 1.03% of the administered dose. Plateau of99mTc-Nanocis accumulation in the lymph node (average 2.05%) occurred at 2 hour of the study and remained almost on the same level (in average 2.3%) to 24 hours. Thus, the experimental study of a new domestic radiopharmaceutical showed that the99mTc-Al2O3several times actively accumulates in the lymph nodes as compared to imported analogue and its practical application will facilitate intraoperative identification of sentinel lymph nodes.