The use of 99mTc-Al2O3 for detection of sentinel lymph nodes in cervical cancer patients

8th International Scientific Conference "Issues of Physics and Technology in Science, Industry and Medicine"

物理学;工业技术;医药卫生

Sinilkin, I.G.^1,2 ; Chernov, V.I.^1,2 ; Lyapunov, A.Yu.^1 ; Medvedeva, A.A.^1,2 ; Zelchan, R.V.^1,2 ; Chernyshova, A.L.^1 ; Kolomiets, L.A.^1,3

Tomsk Cancer Research Institute, Kooperativny street, 5, Tomsk, Russia^1

Tomsk Polytechnic University, Lenina street, 30, Tomsk, Russia^2

Siberian State Medical University, Moskovsky Trakt, 2, Tomsk, Russia^3

关键词: Cancer research;    Cervical cancers;    Intra-operative;    Sentinel lymph nodes;    SPECT images;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/135/1/012043/pdf
DOI  :  10.1088/1757-899X/135/1/012043

来源: IOP

【 摘 要 】

The purpose of the study was to evaluate the feasibility of using 99mTc-Al2O3- based radiopharmaceutical, a novel molecular imaging agent for sentinel lymph node detection in patients with invasive cervical cancer. The study included 23 cervical cancer patients (TlaNxMx- T2bNxMx) treated at the Tomsk Cancer Research Institute. At 18 hours before surgery, 80 MBq of the 99mTc-Al2O3were injected peritumorally, followed by single-photon emission computed tomography (SPECT) of the pelvis and intraoperative SLN identification. Twenty-seven SLNs were detected by SPECT, and 34 SLNs were identified by intraoperative gamma probe. The total number of identified SLNs per patient ranged from 1 to 3(the mean number of SLNs was 1.4 per patient). The most common site for SLN detection was the external iliac region (57.2%), followed by the internal iliac, obturator, presacral and retrosacral regions (they amounted to 14%, respectively),and the parametrial region (1%). Sensitivity in detecting SLNs was 100% for intraoperative SLN identification and 79% for SPECT image.