BMC Microbiology | |
Homology analysis between clinically isolated extraintestinal and enteral Klebsiella pneumoniae among neonates | |
article | |
Chen, Chun-mei1  Wang, Min1  Li, Xian-ping1  Li, Peng-ling2  Tian, Jing-jing1  Zhang, Kan1  Luo, Can1  | |
[1] Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University;Department of Laboratory Medicine, Jiangxi Cancer Hospital | |
关键词: Klebsiella pneumoniae; Gastrointestinal colonization; Multiple locus sequence typing; Endogenic infection; Antibiotic resistance; | |
DOI : 10.1186/s12866-020-02073-2 | |
学科分类:放射科、核医学、医学影像 | |
来源: BioMed Central | |
【 摘 要 】
Klebsiella pneumoniae is a leading cause of hospital-associated (HA) infections. It has been reported that gastrointestinal colonization (GI) is likely to be a common and significant reservoir for the transmission and infections of K. pneumoniae in both adults and neonates. However, the homologous relationship between clinically isolated extraintestinal and enteral K. pneumoniae in neonates hasn’t been characterized yet. Forty-three isolates from 21 neonatal patients were collected in this study. The proportion of carbapenem resistance was 62.8%. There were 12 patients (12/21, 57.4%) whose antibiotic resistance phenotypes, genotypes, and ST types (STs) were concordant. Six sequence types were detected using MLST, with ST37 and ST54 being the dominant types. The results of MLST were consist with the results of PFGE. These data showed that there might be a close homologous relationship between extraintestinal K. pneumoniae (EXKP) and enteral K. pneumoniae (EKP) in neonates, indicating that the K. pneumoniae from the GI tract is possibly to be a significant reservoir for causing extraintestinal infections.
【 授权许可】
CC BY|CC0
【 预 览 】
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