BMC Microbiology | |
Homology analysis between clinically isolated extraintestinal and enteral Klebsiella pneumoniae among neonates | |
Peng-ling Li1  Jing-jing Tian2  Kan Zhang2  Can Luo2  Chun-mei Chen2  Xian-ping Li2  Min Wang2  | |
[1] Department of Laboratory Medicine, Jiangxi Cancer Hospital, Nanchang, Jiangxi, China;Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, 139 Renmin Road, 410011, Changsha, Hunan, China; | |
关键词: Klebsiella pneumoniae; Gastrointestinal colonization; Multiple locus sequence typing; Endogenic infection; Antibiotic resistance; | |
DOI : 10.1186/s12866-020-02073-2 | |
来源: Springer | |
【 摘 要 】
BackgroundKlebsiella pneumoniae is a leading cause of hospital-associated (HA) infections. It has been reported that gastrointestinal colonization (GI) is likely to be a common and significant reservoir for the transmission and infections of K. pneumoniae in both adults and neonates. However, the homologous relationship between clinically isolated extraintestinal and enteral K. pneumoniae in neonates hasn’t been characterized yet.ResultsForty-three isolates from 21 neonatal patients were collected in this study. The proportion of carbapenem resistance was 62.8%. There were 12 patients (12/21, 57.4%) whose antibiotic resistance phenotypes, genotypes, and ST types (STs) were concordant. Six sequence types were detected using MLST, with ST37 and ST54 being the dominant types. The results of MLST were consist with the results of PFGE.ConclusionsThese data showed that there might be a close homologous relationship between extraintestinal K. pneumoniae (EXKP) and enteral K. pneumoniae (EKP) in neonates, indicating that the K. pneumoniae from the GI tract is possibly to be a significant reservoir for causing extraintestinal infections.
【 授权许可】
CC BY
【 预 览 】
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RO202106287340317ZK.pdf | 889KB | download |