The Association Between Common Clinical Characteristics and Postoperative Morbidity and Overall Survival in Patients with Glioblastoma

The oncologist

article

Wenli Liu¹  Aiham Qdaisat²  Jason Yeung²  Gabriel Lopez¹  Jeffrey Weinberg³  Shouhao Zhou⁴  Lorenzo Cohen¹  Eduardo Bruera¹  Sai-Ching J. Yeung² 

[1] Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center;Department of Emergency Medicine, The University of Texas MD Anderson Cancer Center;Department of Neurosurgery, The University of Texas MD Anderson Cancer Center;Department of Biostatistics, The University of Texas MD Anderson Cancer Center;Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center

关键词: Blood pressure;    Blood glucose;    Serum albumin;    Postoperative complications;    Survival;    Glioblastoma;   

DOI  :  10.1634/theoncologist.2018-0056

学科分类：地质学

来源: AlphaMed Press Incorporated

【 摘 要 】

Background The impact of noncancerous factors on the morbidity and mortality of glioblastoma multiforme (GBM) has not been well studied. Using a large surgical cohort, we examined the association between multiple clinical characteristics and postoperative morbidities and survival in patients with GBM. Materials and Methods The study included 404 consecutive GBM patients who underwent initial tumor resection at MD Anderson Cancer Center between January 1, 2010, and December 31, 2014. Data about clinical characteristics, treatments, and postoperative complications were collected. The associations between clinical parameters and postoperative complications and survival were analyzed. Results Charlson Comorbidity Index was positively related to a higher incidence of postoperative total (odds ratio [OR] = 1.20; p  = .002) and neurological (OR = 1.18; p  = .011) complications. Preoperative systolic blood pressure (SBp) over 140 mmHg was associated with a higher incidence of postoperative intracranial hemorrhage (OR = 4.42; p  = .039) and longer hospital stay (OR = 2.48; p  = .015). Greater postoperative fluctuation of SBp (OR = 1.14; p  = .025) and blood glucose (mmol/L; OR = 1.48; p  = .023) were related to a higher incidence of neurological complications, whereas higher postoperative blood glucose (OR = 0.64; p  < .001) was related to a lower incidence. Long-term lower SBp (<124 mmHg; hazard ratio [HR] = 1.47; p  = .010) and higher blood glucose (HR = 1.12; p  < .001) were associated with shorter survival. Long-term serum albumin level (g/dL; HR = 0.32; p  < .001) was positively associated with survival. Conclusion Short-term SBp and blood glucose levels and fluctuations are associated with postoperative complications in GBM patients. Their long-term optimization may impact survival of these patients. Future clinical trials are needed to confirm the benefit of optimizing medical comorbidities on GBM patients' outcomes. Implications for Practice Glioblastoma multiforme (GBM) is one of the most feared cancer diagnoses because of its limited survival and treatment. This study revealed significant associations of noncancerous factors on the morbidity and mortality of GBM. The complexity of medical comorbidities, as well as short-term postoperative levels and fluctuations of blood pressure and blood glucose, was associated with postoperative complications, but not overall survival. However, long-term levels of these common clinical parameters were significantly associated with survival. Optimization of medical conditions may be critical for reducing the morbidity and mortality of GBM patients. Future clinical trials are needed to validate the observed associations in an independent cohort.

【 授权许可】

CC BY|CC BY-NC