Bovine Serum Albumin binding to CoCrMo nanoparticles and the influence on dissolution

Electron Microscopy and Analysis Group Conference 2015

Simoes, T.A.^1 ; Brown, A.P.^1 ; Milne, S.J.^1 ; Brydson, R.M.D.^1

Institute for Materials Research, SCAPE, University of Leeds, LS2 9JT, United Kingdom^1

关键词: Bovine serum albumins;    Corrosion behaviour;    Health complications;    Joint replacement;    Metal-on-metal hip implants;    Preferential binding;    Protein coronas;    Serum albumin;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/644/1/012039/pdf
DOI  :  10.1088/1742-6596/644/1/012039

来源: IOP

【 摘 要 】

CoCrMo alloys exhibit good mechanical properties, excellent biocompatibility and are widely utilised in orthopaedic joint replacements. Metal-on-metal hip implant degradation leads to the release of metal ions and nanoparticles, which persist through the implant's life and could be a possible cause of health complications. This study correlates preferential binding between proteins and metal alloy nanoparticles to the alloy's corrosion behaviour and the release of metal ions. TEM images show the formation of a protein corona in all particles immersed in albumin containing solutions. Only molybdenum release was significant in these tests, suggesting high dissolution of this element when CoCrMo alloy nanoparticles are produced as wear debris in the presence of serum albumin. The same trend was observed during extended exposure of molybdenum reference nanoparticles to albumin.