The role of HBD-2, HBD-3, and calprotectin in the relationship between chronic periodontitis and atherosclerosis

Biocell

article

MEHMET TASPINAR¹  ALIHAN BOZOGLAN³  ABDULLAH SECKIN ERTUGRUL⁵  LEVENT ELMAS⁶ 

[1] Faculty of Medicine, Aksaray University;Faculty of Medicine, Yuzuncu Yil University;Department of Periodontology, Faculty of Dentistry, Fırat University;Department of Periodontology, Faculty of Dentistry, Yuzuncu Yil University;Department of Periodontology, Faculty of Dentistry, İzmir Katip Çelebi University;Faculty of Medicine, Pamukkale University

关键词: Atherosclerosis;    Periodontal Diseases;    HBD-2;    HBD-3;    Calprotectin;   

DOI  :  10.32604/biocell.2020.011470

学科分类：仪器

来源: Biocell

【 摘 要 】

This study was carried out to compare individuals diagnosed with atherosclerosis and periodontal periodontitis based on the degree of change in the human beta-defensins (HBD) HBD-2, HBD-3, and calprotectin. Atherosclerosis is the most frequently observed cardiovascular disease. Dental and periodontal infections are known to provide a considerable basis for atheroma plaque formation. The study group consists of a total number of 40 subjects, with 20 patients diagnosed with atherosclerosis and chronic periodontitis and 20 systemically healthy patients diagnosed with chronic periodontitis. Clinical periodontal and blood parameters and HBD-2, HBD-3, and calprotectin biomarkers in the gingival crevicular fluid were measured. In both groups, following clinical periodontal treatment, a statistically significant decrease in white blood cells (WBC), low-density lipoproteins (LDL), fibrinogen, creatinine, and platelets (PLT), a statistically significant increase in high-density lipoproteins (HDL) in blood samples, statistically meaningful decrease in HBD-2, HBD-3, and calprotectin in the gingival crevicular fluid were achieved. Blood values and HBD-2, HBD-3, calprotectin amounts in the gingival crevicular fluid were increased significantly in the test group compared to the control group. A positive correlation was observed between decreases in HBD-2, HBD-3, calprotectin, and clinical periodontal indices. Regression in systemic inflammation was observed after clinical periodontal treatment. It is concluded that nonsurgical periodontal treatment of chronic periodontitis positively affects atherosclerosis prognosis.

【 授权许可】

CC BY