Effects of α-mangostin on embryonic development and liver development in zebrafish

Molecular & Cellular Toxicology

article

Pimtong, Wittaya¹  Kitipaspallop, Wannakarn²  Chun, Hang-Suk³  Kim, Woo-Keun³ 

[1] Nano Environmental and Health Safety Research Team, National Nanotechnology Center, National Science and Technology Development Agency;Department of Biology, Faculty of Science, Chulalongkorn University;Biosystem Research Group, Korea Institute of Toxicology

关键词: α-Mangostin;    Xanthone;    Zebrafish;    Hepatogenesis;    Toxicity;   

DOI  :  10.1007/s13273-020-00099-1

来源: Korean Society of Toxicogenomics and Toxicoproteomics

【 摘 要 】

Background Alpha-mangostin has potential as a chemopreventive agent but there is little information on its toxicological profile and developmental toxicity. Objective We evaluated the effects of α-mangostin on embryonic development and hepatogenesis in zebrafish. Result Exposure of embryos to 0.25–4 μM α-mangostin from 4–120 h post-fertilization (hpf) caused mortality of embryos with LC50 1.48 ± 0.29 μM. The compound also caused deformities, including head malformation, pericardial oedema, absence of swim bladder, yolk oedema, and bent tail. Exposure of zebrafish embryos to α-mangostin during early hepatogenesis (16–72 hpf) decreased the transcript expression levels of liver fatty acid-binding protein 10a (Fabp10a), but increased gene markers of inflammation, oxidative stress, and apoptosis. In Fabp10a:DsRed transgenic zebrafish, the intensity and the area of fluorescence in the liver of the treated group were decreased (non-significantly) relative to controls. Conclusion These effects were more marked during early hepatogenesis (16–72 hpf) than during post-hepatogenesis (72–120 hpf).

【 授权许可】

Unknown