Hyaluronic acid as a bioactive component for bone tissue regeneration: Fabrication, modification, properties, and biological functions

Nanotechnology Reviews

article

Fei Xing¹  Lei Liu¹  Zhou Xiang¹  Xingdong Zhang²  Changchun Zhou²  Didi Hui⁴  Colin Du⁴  Lina Wu²  Linnan Wang¹  Wenzhao Wang¹  Xiaobing Pu⁵  Linxia Gu⁶ 

[1] Department of Orthopaedics, West China Hospital, Sichuan University;National Engineering Research Center for Biomaterials, Sichuan University;College of Biomedical Engineering, Sichuan University;Innovatus Oral Cosmetic & Surgical Institute, United States of America;Department of Orthopedics Medical Center, West China School of Public Health and West China Fourth Hospital, Sichuan University;Department of Biomedical and Chemical Engineering and Sciences, College of Engineering & Science, Florida Institute of Technology, United States of America

关键词: bioactive component;    hyaluronic acid;    bone regeneration;    3D printing;    tissue engineering;   

DOI  :  10.1515/ntrev-2020-0084

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

Hyaluronic acid (HA) is widely distributed in the human body, and it is heavily involved in many physiological functions such as tissue hydration, wound repair, and cell migration. In recent years, HA and its derivatives have been widely used as advanced bioactive polymers for bone regeneration. Many medical products containing HA have been developed because this natural polymer has been proven to be nontoxic, noninflammatory, biodegradable, and biocompatible. Moreover, HA-based composite scaffolds have shown good potential for promoting osteogenesis and mineralization. Recently, many HA-based biomaterials have been fabricated for bone regeneration by combining with electrospinning and 3D printing technology. In this review, the polymer structures, processing, properties, and applications in bone tissue engineering are summarized. The challenges and prospects of HA polymers are also discussed.

【 授权许可】

CC BY