Synthesis and biological activity studies of some new hybrid compounds derived from antipyrine

Heterocyclic communications

article

Serpil Demirci¹ 

[1] Giresun University, Kadir Karabas School of Applied Sciences, Department of Crop Production and Technologies

关键词: antimicrobial activity;    antipyrine;    Mannich reaction;    microwave;   

DOI  :  10.1515/hc-2016-0002

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

N -Benzyl- N ′-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1 H -pyrazol-4-yl)urea (1) was obtained from antipyrine. The reaction of 1 with ethyl bromoacetate produced the 1,3-oxazole derivative 2 . Compounds 5a–c were obtained from antipyrine by three steps via intermediary of the ester 3 and hydrazide 4 . The microwave supported cyclocondensation of 5a–c with 4-chlorophenacyl bromide and ethyl bromoacetate afforded the corresponding 1,3-thiazoles 6 or 1,3-thia(oxa)zolidines 7 . The intramolecular cyclization of 5a–c in the presence of NaOH produced the corresponding triazoles 8a–c . The synthesis of the hybrid compound 9 containing a penicillin skeleton was carried out by the treatment of 8a with (+)-6-aminopenicillanic acid (6-apa) in the presence of formaldehyde. The structural assignments of new compounds were based on their elemental analysis and spectral (IR, 1 H-NMR, 13 C-NMR and LC-MS) data. All compounds except 1 and 7b show moderate antimicrobial activity.

【 授权许可】

CC BY|CC BY-NC-ND