Synthesis and antimicrobial activity evaluation of new norfloxacine-azole hybrids

Heterocyclic communications

article

Serpil Demirci¹  Neslihan Demirbaş²  Meltem Menteşe²  SerapBaşoğlu Özdemir²  Şengül A. Karaoğlu³ 

[1] Giresun University, Vocational High School of Health Services Department of Medical Services and Techniques;Karadeniz Technical University, Department of Chemistry;Recep Tayyip Erdoğan University, Department of Biology

关键词: antimicrobial activity;    microwave;    norfloxacin;    one-pot;    1;    3;    4-oxadiazole;    three-component reaction;    1;    2;    4-triazole;   

DOI  :  10.1515/hc-2018-0070

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Norfloxacin-azole hybrids 3 and 6a,b were synthesized starting from norfloxacin. The treatment of these compounds with amines as a one-pot three-component reaction produced the corresponding amino derivatives 4a,b , 7a–g and 8a,b in good yields. The conventional and microwave-assisted methods were used with the latter method being more efficient. The structures of the synthesized compounds were characterized by elemental analysis, IR, 1 H NMR, 13 C NMR and MS. All compounds were screened for their antimicrobial activities. Most of them exhibit excellent antibacterial activity but are not active against selected fungi.

【 授权许可】

CC BY|CC BY-NC-ND