Microwave Assisted Synthesis of Some New Heterocyclic Spiro-Derivatives with Potential Antimicrobial and Antioxidant Activity

Molecules

Mohamed Mohamed Youssef¹ 

[1] ¹Chemistry Department, Faculty of Science, Cairo University, Egypt ²Chemistry Department, Faculty of Science, Suez Canal University, Egypt ^†Current Address: Chemistry Department, Faculty of Science, Taif University, Saudi Arabia.

关键词: microwave;    spiro-compounds;    heterocycles;    spiro-benzoxazoleisoquinoline;    spiro-benzimidazoleisoquinoline;    spiro-isoquinolinetriazole;    spiro-isoquinolinepyrazole;    spiro-isoquinolinepyrimidine;    antimicrobial activity;    antioxidant activity;   

DOI  :  10.3390/molecules15128827

来源: mdpi

【 摘 要 】

Homophthalic anhydride reacts with different aromatic amines to produce N-substituted homophthalimides. Bromination of the latter produces 4,4-dibromo-homophthalimide derivatives that can be used as precursors for spiro-derivatives. The dibromo derivatives react with different binucleophilic reagents to produce several spiro-isoquinoline derivatives. Reaction of the dibromo derivatives with malononitrile produces dicyanomethylene derivatives which react with different binucleophiles to produce new spiro-derivatives. Structures of the newly synthesized compounds are proved using spectroscopic methods such as IR, ¹H-NMR and ¹³C-NMR. The newly synthesized compounds were tested for their antimicrobial and antioxidant activities, showing weak or no antimicrobial activity. On the other hand select compounds showed promising antioxidant activities.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.