Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds

Heterocyclic communications

article

Serap Basoglu Ozdemir¹  Yıldız Uygun Cebeci¹  Hacer Bayrak²  Arif Mermer¹  Sule Ceylan³  Ahmet Demirbas¹  Sengul Alpay Karaoglu⁴  Neslihan Demirbas¹ 

[1] Karadeniz Technical University, Department of Chemistry;Karadeniz Technical University, Department of Chemistry and Chemical Processing Technology;Artvin Coruh University, Department of Occupational Health and Safety;Recep Tayyip Erdoğan University, Department of Biology

关键词: antimicrobial activity;    conazole;    Mannich base;    microwave;    piperazine;   

DOI  :  10.1515/hc-2016-0125

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

The hydrazide 5 , that was obtained from 1-(4-fluorophenyl)piperazine ( 1 ), was converted to the corresponding carbothioamides 6a–c by the reaction with alkyl(aryl) isothiocyanates. The synthesis of conazole analogs 10a–f was performed via the intermediary of triazoles 7a–c . The condensation of triazoles 7a–c with several heterocyclic amines in the presence of formaldehyde afforded the corresponding N -aminoalkylated triazoles 11–14 . The effect of different catalysts and solvents on conventional and microwave (MW)-prompted reactions was examined. The synthesized compounds were screened for their antimicrobial activities.

【 授权许可】

CC BY|CC BY-NC-ND