Surveillance for antiviral resistance

Influenza and Other Respiratory Viruses

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关键词: Neuraminidase inhibitor;    antiviral susceptibility;    monitoring;    transmission;   

DOI  :  10.1111/irv.12050

来源: Wiley

【 摘 要 】

Abstract

Please cite this paper as: Zambon. (2012) Surveillance for antiviral resistance. Influenza and Other Respiratory Viruses 7(Suppl. 1), 37–43.

In the 10 years since licensure of neuraminidase inhibitor drugs, their use has steadily increased, especially during the pandemic of 2009. Experience now indicates that factors which influence the emergence of high level resistance include the nature of drug binding to target, viral subtype, the use of post exposure prophylaxis and a lack of immunity in the host as seen in children and immunocompromised individuals. These factors point towards targetted surveillance programmes for the early identification of transmissible drug resistance.

【 授权许可】

Unknown   
© 2012 Blackwell Publishing Ltd