Antiviral Susceptibilities of Avian Influenza A(H5), A(H7), and A(H9) Viruses Isolated in Japan

Japanese journal of infectious diseases

article

Emi Takashita¹  Hiroko Morita¹  Shiho Nagata¹  Masayuki Shirakura¹  Seiichiro Fujisaki¹  Hideka Miura¹  Ikuyo Takayama¹  Tomoko Arita¹  Yasushi Suzuki¹  Masaoki Yamaoka²  Taichiro Tanikawa³  Ryota Tsunekuni⁴  Junki Mine⁴  Saki Sakuma⁴  Yuko Uchida⁴  Akihiro Shibata⁵  Mari Iwanaka⁵  Noriko Kishida¹  Kazuya Nakamura¹  Tsutomu Kageyama¹  Shinji Watanabe¹  Hideki Hasegawa¹ 

[1] Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases;Hyogo Prefectural Institute of Public Health Science;Virus group, Division of Infectious Animal Disease Research, National Institute of Animal Health, National Agriculture and Food Research Organization;Emerging Virus Group, Division of Zoonosis Research, National Institute of Animal Health, National Agriculture and Food Research Organization;Animal Quarantine Service, Ministry of Agriculture

关键词: avian influenza;    antiviral susceptibility;    neuraminidase inhibitor;    RNA polymerase inhibitor;   

DOI  :  10.7883/yoken.JJID.2021.751

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

The circulation of avian influenza A viruses in poultry is a public health concern due to the potential transmissibility and severity of these viral infections. Monitoring the susceptibility of these viruses to antivirals is important for developing measures to strengthen the level of preparedness against influenza pandemics. However, drug susceptibility information on these viruses is limited. Here, we determined the susceptibilities of avian influenza A(H5N1), A(H5N2), A(H5N8), A(H7N7), A(H7N9), A(H9N1), and A(H9N2) viruses isolated in Japan to the antivirals approved for use there: an M2 inhibitor (amantadine), neuraminidase inhibitors (oseltamivir, peramivir, zanamivir, and laninamivir) and RNA polymerase inhibitors (baloxavir and favipiravir). Genotypic methods that detect amino acid substitutions associated with antiviral resistance and phenotypic methods that assess phenotypic viral susceptibility to drugs have revealed that these avian influenza A viruses are susceptible to neuraminidase and RNA polymerase inhibitors. These results suggest that neuraminidase and RNA polymerase inhibitors currently approved in Japan could be a treatment option against influenza A virus infections in humans.

【 授权许可】

Unknown