Design and Synthesis of a Cyclopentene Scaffold Mimicking Oseltamivir as a Novel Neuraminidase Inhibitor

Bulletin of the Korean chemical society

Joon Hee Hong¹  Fushan Piao¹ 

关键词: Neuraminidase inhibitor;    Zanamivir;    Oseltamivir;    Cyclopentene scaffold;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The first synthesis of a cyclopentene version of oseltamivir as a novel neuraminidase inhibitor was achieved via the key cyclopentenone intermediate 4, which was prepared via syn-elimination from ketone derivative 2.

【 授权许可】

Unknown