Rapid and robust reversion to essential thrombocythemia on treatment with Decitabine in a case of hydroxyurea‐induced t‐MDS/AML

Clinical Case Reports

Joshua D. Horton²  Arnaldo A. Arbini¹  Mary Ann Perle¹ 

[1] Department of Pathology, New York University Medical Center, New York, New York;New York University School of Medicine, New York, New York

关键词: Acute leukemia;    chemotherapy;    essential thrombocythemia;    hydroxyurea;    leukemia cytogenetics;    megakaryocyte;   

DOI  :  10.1002/ccr3.431

来源: Wiley

【 摘 要 】

Key Clinical Message

Rapid remission of MDS/AML may be induced with Decitabine; however, significant megakaryocyte expansion and subsequent thrombocytosis may occur. Decitabine-mediated reversion of the MDS to benign ET via hypomethylation of JAK/STAT pathway repressors is one potential mechanism to explain this observed phenomenon.

【 授权许可】

CC BY-NC-ND   
© 2015 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

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