Case Report: Long-Term Chemotherapy With Hydroxyurea and Prednisolone in a Cat With a Meningioma: Correlation of FDG Uptake and Tumor Grade Assessed by Histopathology and Expression of Ki-67 and p53

Frontiers in Veterinary Science

Wonguk Lee¹  Soochong Kim²  Dong-In Jung³  Byeong-Teck Kang⁴  Taesik Yun⁴  Yoonhoi Koo⁴  Mhan-Pyo Yang⁴  Hakhyun Kim⁴ 

[1] Department of Nuclear Medicine, Chungbuk National University Hospital, Cheongju, South Korea;Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea;Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, South Korea;Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea;

关键词: brain tumor;    chemotherapy;    feline;    hydroxyurea;    positron emission tomography;   

DOI  :  10.3389/fvets.2021.576839

来源: DOAJ

【 摘 要 】

A 15.5-year-old, neutered, male, domestic shorthair cat was presented with neurologic dysfunctions. At presentation, an obtunded mental status and vestibular ataxia were identified. On neurologic examination, postural reactions were decreased-to-absent in all four limbs, and pupillary light reflexes showed bilaterally delayed results. Magnetic resonance imaging was performed, and a demarcated lesion was identified in the third ventricle. The cat was tentatively diagnosed with a brain tumor, which was suspected to be a meningioma. The cat was treated with hydroxyurea and prednisolone. Mental status was considered more alert, and ataxia improved following treatment. On the 106th day after the commencement of treatment, a 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) scan was performed. On the PET images, a hypermetabolic region was found in the lesion. The average standardized uptake value of FDG was 2.47, and the tumor-to-normal-tissue ratio was 1.25. The cat died 408 days following the commencement of treatment, and a grade 1 meningioma was confirmed by postmortem histopathology. Immunohistochemistry for Ki-67 and p53 was performed. The labeling indices of Ki-67 and p53 were 2.56 and 0%, respectively. This case shows that chemotherapy with hydroxyurea and prednisolone may be considered in the treatment of feline meningiomas. Furthermore, this is the first case describing the application of FDG-PET to visualize a naturally occurring meningioma in a cat.

【 授权许可】

Unknown