The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications

Frontiers in Cardiovascular Medicine

Brenda Lilly¹  Randa M. Breikaa² 

[1] Center for Cardiovascular Research and The Heart Center, Nationwide Children's Hospital, Columbus, OH, United States;Department of Pediatrics, The Ohio State University, Columbus, OH, United States;Center for Cardiovascular Research and The Heart Center, Nationwide Children's Hospital, Columbus, OH, United States;Molecular, Cellular and Developmental Biology Program, The Ohio State University, Columbus, OH, United States;

关键词: notch signaling pathway;    COVID-19;    cardiovascular;    vascular biology;    cardiovascular disease;   

DOI  :  10.3389/fcvm.2021.681948

来源: Frontiers

【 摘 要 】

COVID-19 is associated with a large number of cardiovascular sequelae, including dysrhythmias, myocardial injury, myocarditis and thrombosis. The Notch pathway is one likely culprit leading to these complications due to its direct role in viral entry, inflammation and coagulation processes, all shown to be key parts of COVID-19 pathogenesis. This review highlights links between the pathophysiology of SARS-CoV2 and the Notch signaling pathway that serve as primary drivers of the cardiovascular complications seen in COVID-19 patients.

【 授权许可】

CC BY