Virchow’s Triad and the Role of Thrombosis in COVID-Related Stroke

Frontiers in Physiology

Mark D. McCauley¹  Francisco J. Gonzalez-Gonzalez²  Mary Rodriguez Ziccardi³ 

[1] Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States;Division of Cardiology, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States;Jesse Brown VA Medical Center, Chicago, IL, United States;

关键词: COVID-19;    stroke;    Virchow’s triad;    thrombosis;    cardiovascular;   

DOI  :  10.3389/fphys.2021.769254

来源: DOAJ

【 摘 要 】

In December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as a virally transmitted disease. Three months later, SARS-CoV-2 became one of the largest pandemics in recent times, causing more than 235 million cases globally, and accounting for at least 4.8 million deaths to date. SARS-COV-2 infection was initially classified as a respiratory tract infection, but later was recognized as a multisystemic disease compromising gastrointestinal, hematological, cardiac, and neurological systems. With this Review, we aim to describe the epidemiology, risk factors, mechanisms, and management of cerebrovascular events in patients infected with COVID-19. Neurological manifestations related to thromboembolic cerebrovascular events in patients infected with COVID-19 have been frequent and associated with poor prognosis in the majority of cases. A better understanding of the mechanisms of thrombosis and etiologies of this new disease process are necessary to determine how to prevent and treat patients to reduce their length of stay, morbidity, and mortality.

【 授权许可】

Unknown