Enhanced anti-cancer activity by co-delivery of docetaxel and perifosine with multifunctional nanoparticles via regulation of PI3K/Akt signalling pathway

Micro & nano letters

article

Jingjing Chen¹  Xiangyuan Bu¹  Qi Shen¹ 

[1] School of Pharmacy, Shanghai Jiao Tong University

关键词: cancer;    drugs;    drug delivery systems;    nanoparticles;    nanomedicine;    cellular biophysics;    tumours;    biomedical materials;    electrokinetic effects;    cytotoxic drug antitumor activity;    docetaxel antitumor activity;    docetaxel codelivery;    docetaxel evaluation;    drug resistance development;    DTX antitumor activity;    DTX evaluation;    DTX loaded Fol-R7 nanoparticle cell uptake;    DTX loaded Fol-R7 nanoparticle cytotoxicity;    DTX loaded Fol-R7 nanoparticle early apoptosis;    folate-R7 nanoparticle;    folate-R7 NP;    Fol-R7 NP-enhanced PI3K-Akt inhibition effect;    MCF-7 apoptosis;    MCF-7 cell viability;    MCF-7 cellular uptake;    MCF-7-Adr apoptosis;    MCF-7-Adr cell viability;    MCF-7-Adr cellular uptake;    multifunctional nanoparticles;    nanoparticle anticancer activity;    nanoparticle morphology evaluation;    nanoparticle size evaluation;    nanoparticle zeta potential evaluation;    perifosine codelivery;    perifosine co-loaded nanoparticle;    perifosine loaded Fol-R7 NP cell uptake;    perifosine loaded Fol-R7 NP cytotoxicity;    perifosine loaded Fol-R7 NP early apoptosis;    phosphoinositide 3-kinase;    PI3K/Akt signalling pathway regulation;    PI3K-Akt inhibition effect assessment;    PI3K-Akt inhibitor nanoparticle;    PI3K-Akt-associated drug resistance;    protein kinase B;    Western blotting-assessed P13K-Akt inhibition;   

DOI  :  10.1049/mnl.2014.0661

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Only in a few decades, ultrasonography has revolutionized the diagnostic approach in many of the medical specialties. Although the obstetricians were the first ones to use it to the advantage of the patients, many other medical and surgical specialties followed them. Anesthesiologists were not very late in this race, and they soon studied and found its multiple uses in the practice of anesthesiology, interventional pain management, intensive care, trauma and resuscitation. Huge cost on the ultrasound machines, administrative inertias and lack of adequate training facilities have been the main obstacles in adopting this modality to its full potential in non-developed countries. It’s the need of the time that cheaper but adequate versions of the machines are developed and due stress is laid on the professional training in its use at all postgraduate training courses. Ultrasound is here to stay!.

【 授权许可】

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