Magnetic/pH dual-responsive nanocomposites loading doxorubicin hydrochloride for cancer therapy

Micro & nano letters

article

Tingting Zhang¹  Kun Zhang¹  Feng Jiang¹  Jianfeng Zhang¹  Xin Song²  Jinshun Zhao² 

[1] Faculty of Materials Science and Chemical Engineering, Ningbo University;Faculty of Medicine, Ningbo University

关键词: visible spectra;    graphene;    drugs;    X-ray diffraction;    magnetic particles;    cancer;    condensation;    drug delivery systems;    ultraviolet spectra;    nanomedicine;    hydrogen bonds;    nanomagnetics;    nanofabrication;    scanning electron microscopy;    tumours;    biomedical materials;    nanoparticles;    nanocomposites;    pH;    Fourier transform infrared spectra;    filled polymers;    iron compounds;    thermal analysis;    magnetometers;    pH-responsive release behaviour;    magnetic targeted drug delivery system;    cancer therapy;    PEGylated citric-coated Fe3O4-graphene oxide nanocomposites;    magnetic nanoparticles;    magnetic-pH dual-responsive nanocomposite;    doxorubicin hydrochloride;    amide condensation reaction;    polyethylene glycol;    citric acid;    X-ray diffraction;    scanning electron microscopy;    Fourier transform-infrared spectrocopy;    ultraviolet–visible spectroscopy;    thermogravimetry;    vibrating sample magnetometer;    hydrogen bond;    drug loading content;    tumour growth;    Fe3O4;   

DOI  :  10.1049/mnl.2018.5541

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Metoprolol is a β1 adrenergic blocker used in treatment of heart diseases. Metoprolol (100mg) tablets was formulated as a modified release oral system utilizing the concept of bilayer system, first layer contained (30mg) as immediate release and the other (70mg) in the sustained release matrix.  The immediate release layer consisted of lactose or microcrystalline cellulose as diluents with sodium starch glycolate or sodium croscarmellose as disintegrants. The result showed that the layer contains microcrystalline cellulose and 2% sodium starch glycolate gave disintegration time similar to that of conventional metoprolol tartrate tablet. This result was subjected in the subsequent preparation of the bilayer tablet. The sustained release layer was prepared using three polymers: ethylcellulose (EC), Hydroxypropyl methylcellulose (HPMC) and hydroxyl ethylcellulose (HEC) as retardant materials. It was found that the combination of EC with HPMC in ratio of 2:1 in F11 was best formula because of it’s release profile and the tablet integrity and dimensions were conserved for the period of the test, but according to similarity factor (f ­2­), F15 (which contained EC:HPMC in ratio 2:1 with polyvinyl pyrrolidone (PVP) as a binder) was the best formula showed higher (f2­) among all other formulas and equals to 72.3 comparing to reference product.

【 授权许可】

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