Rapid fabrication of circular channel microfluidic flow-focusing devices for hydrogel droplet generation

Micro & nano letters

article

Benjamin Parker¹  Roya Samanipour¹  Ali Ahmadi¹  Keekyoung Kim¹ 

[1] School of Engineering, University of British Columbia

关键词: microfluidics;    hydrogels;    casting;    three-dimensional printing;    microfabrication;    moulding;    curing;    drops;    microfluidic chip;    liquid PDMS injection process;    oxygen plasma treatment;    curing 20 problem;    microfluidic mould;    3D printer;    microfabrication method;    three dimensional printing process;    PDMS casting;    polydimethylsiloxane;    hydrogel droplet generation;    circular channel microfluidic flow-focusing device;   

DOI  :  10.1049/mnl.2015.0329

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Objective: Post dural puncture headache (PDPH) is one of major complications of spinal anesthesia. There are two approaches to administer spinal anesthesia i.e. median and paramedian. We conducted this study to compare the frequency of PDPH after spinal anesthesia for cesarean section with median versus paramedian approach using 25 gauge pencil point needle. Methodology: This randomized controlled trial was conducted at Departments of Anesthesiology, Surgical Intensive Care & Pain Management Centre as well as Gynecology & Obstetrics, Peoples University of Medical & Health Sciences, Nawabshah, Benazirabad (Pakistan). One hundred and twenty females underwent elective cesarean section under spinal anesthesia were enrolled. After informed written consent, the parturients were randomly divided into two equal groups by lottery method; Group A patients received spinal block with median approach and Group B patients received it with paramedian approach. All spinal blocks were performed with 25 gauge pencil point needle. The patients were asked about the presence or absence of headache through Visual Analogue Scale (VAS) in the next 72 hours. Results: In median approach (Group A), 3 patients (5%) had PDPH; whereas in paramedian approach (Group B) only 1 patient (1.6%) had PDPH. All the patients were of younger age and low parity. They developed PDPH within 24 -48 hours which was of mild to moderate in degree on VAS and relieved by rest, plenty of fluids and simple analgesics containing caffeine in mild case. While strong analgesics and muscle relaxants were added in cases of moderate PDPH. PDPH was relieved within 2-3 days in all cases without any complication. The difference was statistically insignificant (p-value=0.30). Conclusion: Paramedian approach is better than median approach in terms of reduction in the frequency of PDPH, though the results were statistically insignificant.

【 授权许可】

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