Transparent and flexible force sensor based on microextrusion 3D printing

Micro & nano letters

article

Runhuai Yang¹  Tianyun Gao¹  Didi Li¹  Yueming Chen¹  Guoqing Jin³  Haiyi Liang⁴  Fuzhou Niu⁶ 

[1] Department of Biomedical Engineering, School of Life Science, Anhui Medical University;Runhuai Yang and Tianyun Gao contributed equally to this work;Robotics and Microsystems Center, School of Mechanical and Electric Engineering, Soochow University;CAS Key Laboratory of Mechanical Behavior and Design of Materials, University of Science and Technology of China;IAT-Chungu Joint Laboratory for Additive Manufacturing, Institute of Advanced Technology, University of Science and Technology of China;College of Mechanical Engineering, Suzhou University of Science and Technology

关键词: three-dimensional printing;    polymers;    force sensors;    hydrogels;    underwater equipment;    microfabrication;    sandwich structures;    ink;    zig-zag pattern;    PDMS cover layers;    hydrogel sensor;    zig-zag patterned hydrogel;    PDMS layers;    flexible force sensor;    microextrusion 3D printing;    human wearable sensor;    robotic sensor;    slow-gelling alginate hydrogel;    self-designed microextrusion 3D printer;    sensor fabrication;    slow-gelling hydrogel printing ink;    treated PDMS layer;   

DOI  :  10.1049/mnl.2018.5076

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

The present study is to formulate and evaluate Acyclovir (ACV) microspheres using natural polymers like chitosan and sodium alginate. ACV is a DNA polymerase inhibitor used in treating herpes simplex virus infection and zoster varicella infections. Acyclovir is a suitable candidate for sustained-release (SR) administration as a result of its dosage regimen twice or thrice a day and relatively short plasma half-life (approximately 2 to 4 hours). Microspheres of ACV were prepared by an ionic dilution method using chitosan and sodium alginate as polymers. The prepared ACV microspheres were then subjected to FTIR, SEM, particle size, % yield, entrapment efficiency, in vitro dissolution studies and release kinetics mechanism. The FTIR spectra’s revealed that, there was no interaction between polymer and ACV. ACV microspheres were spherical in nature, which was confirmed by SEM. The particle size of microspheres was in the range of 23.8µm to 39.4µm. 72.9% drug entrapment efficiency was obtained in the formulation F3 (1:3 ratio) with a high concentration of calcium chloride (4% w/v). The in vitro performance of ACV microspheres showed sustained release depending on the polymer concentration and concentration of calcium chloride.   The release data was best fitted with zero order kinetics and Korsemeyer -Peppas release mechanism and diffusion exponent ‘n’ value of was found to be Non-Fickian.

【 授权许可】

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