Study on 3D printing technology and mechanical properties of a nano-enhanced composite hydrogel bio-ink

Micro & nano letters

article

Weitao Wu¹ 

[1] School of Mechanical Engineering, Liaoning Equipment Manufacture College of Vocational Technology

关键词: hydrogels;    gelatin;    tensile strength;    curing;    elastic moduli;    nanofabrication;    three-dimensional printing;    creep;    nanocomposites;    compressive strength;    tensile strength;    curing methods;    nanocomposite hydrogel bio-ink;    thermo-sensitive properties;    toughening mechanism;    3D printed structure;    creep deformation;    shear thinning mechanism;    gelatin–alginate–montmorillonite;    ionic crosslinking;    compressive strength;    tensile modulus;    drug delivery;    tissue engineering;    elastic moduli;    size 0.311 mm;   

DOI  :  10.1049/mnl.2019.0712

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Traditional bio-inks are mostly limited in application due to their low-mechanical strength or complex cross-linking curing methods. In this study, a nanocomposite hydrogel bio-ink [gelatin–alginate–montmorillonite (GT–AT–MMT)] for 3D bioprinting is designed based on the thermo-sensitive properties of GT, the advantages of ionic crosslinking of sodium AT, and the shear thinning and toughening mechanism of nano-MMT. The 3D printing of the bio-ink with variable AT content is optimised, and the tensile, compressive, and creep properties of the 3D printed structure are studied. Results show that GT–AT–MMT bio-ink has good printability, and its mechanical properties are enhanced with increased AT content. The tensile modulus of the GT–4% AT–MMT sample can reach 0.533 MPa, which has a minimum creep deformation of 0.311 mm under the same load condition. Therefore, GT–AT–MMT bio-ink provides a new possibility for the development of 3D bioprinting, which will offer many opportunities in fields such as tissue engineering, drug delivery, and regeneration medicine.

【 授权许可】

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