Fabrication and characterisation of new type of magnetic nanoanion exchanger particles for enteric losartan potassium delivery

Micro & nano letters

article

Nazanin Amareh¹  Homayon Ahmad Panahi¹  Farid Moeinpour² 

[1]Department of Chemistry, Central Tehran Branch, Islamic Azad University

[2]Department of Chemistry, Bandar Abbas Branch, Islamic Azad University

关键词: scanning electron microscopy;    nanomedicine;    drug delivery systems;    iron compounds;    nanoparticles;    drugs;    magnetic particles;    biomedical materials;    nanofabrication;    thermal analysis;    filled polymers;    nanomagnetics;    adsorption;    pH;    transmission electron microscopy;    ion exchange;    nanocomposites;    polymer blends;    Fourier transform infrared spectra;    potassium compounds;    magnetic nanoanion exchanger particles;    enteric losartan potassium delivery;    magnetite nanoparticles;    thermogravimetric analysis;    transmission electron microscopy;    exchange parameters;    graft polymer;    brilliant cresyl blue;    polymeric nanoparticles;    Fourier transform infrared spectroscopy;    elemental analysis;    sample pH;    contact time;    functionalised sorbent;    equilibrium adsorption data;    Langmuir analysis;    Freundlich equations;    Dubinin-Radushkevich equations;    Redlich-Peterson equations;    simulated gastric fluid;    simulated intestinal fluid;    enteric drug delivery;    losartan potassium loaded–modified MNPs;    time 15.0 hour;    time 30.0 hour;    Fe2O3;   

DOI  :  10.1049/mnl.2018.0141

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Primary amide derivatives as histone deacetylase inhibitors (HDACIs) are very rare. This paper describes the synthesis of primary amide derivatives (compounds 6 and 7) that have the requirements to be histone deacetylase inhibitors of the zinc-binding type. Both of them exhibited good cytotoxicity against the tested cancer cell lines with much lower cytotoxicity against normal cell line.

【 授权许可】

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