Synthesis of magnetite (Fe 3 O 4 )–Avastin nanocomposite as a potential drug for AMD treatment

Micro & nano letters

article

Mehrzad Zargarzadeh¹  Hamid Reza MadaahHosseini¹  Hamid Delavari²  Rasoul Irajirad³  Ermia Aghaie⁴ 

[1] Department of Material Science and Engineering, Sharif University of Technology (International Campus);Department of Materials Engineering, Tarbiat Modares University;Research Center for Science and Technology in Medicine, Imam Khomeini Hospital;School of Engineering, University of British Columbia – Okanagan, 3333 University Way

关键词: laser applications in medicine;    nanomagnetics;    magnetisation;    molecular biophysics;    biomedical materials;    nanocomposites;    drug delivery systems;    nanofabrication;    vision defects;    cellular biophysics;    drugs;    nanomedicine;    iron compounds;    eye;    precipitation (physical chemistry);    nanoparticles;    surgery;    surgery;    intravitreal injection;    eye pressure;    eye infections;    body organs;    lost vision;    drug delivery technique;    co-precipitation method;    saturation magnetisation;    synthesised iron oxide nanoparticles;    systemic side effects;    AMD treatment;    macular degeneration;    antivascular endothelial growth factor;    magnetite–Avastin nanocomposite synthesis;    age-related macular degeneration;    blindness;    laser therapy;    blurring vision;    flow cytometry;    Fe3O4;   

DOI  :  10.1049/mnl.2017.0820

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Abstract:                                                                                                                Fluoroquinolones drugs are an important class of wide spectrum antibacterial agents, and active against a wide range of Gram-negative and Gram-positive pathogens, are divided into four generations. Collateral damage is a term used to refer to ecological adverse effects of antibiotic therapy, occurring as drug-resistant organisms and the unwanted development of colonization or infection with multidrug-resistant organisms. This damage is mostly related to levofloxacin and Ciprofloxacin.  Aim: The aim of the current study was to compare the incidence of collateral damage between two quinolone antibiotic derivatives (ciprofloxacin and Levofloxacin) and evaluate the activity of lactobacillus to reduce the collateral damage. Patients and Methods: This study was carried out on 100 patients. Administration of ciprofloxacin, levofloxacin each alone or in combination with lactobacillus, the character of diarrhea and grade of diarrhea was studied before and after 10 days of administration each dosing protocol. Results: there are a significant increase in the incidence of diarrhea for all groups when compare between before and after treatment diarrhea, Number of patients with diarrhea in group 1 after finish the treatment was not significantly higher when compared with group 2 (p>0.05) meanwhile number of patients with diarrhea in group 4 after finish the treatment was significantly lower when compared with group 3 (p>0.05). Conclusion; The use of ciprofloxacin and levofloxacin associated with incidence of collateral damage represented as diarrhea and levofloxacin is the least risk of this damage, and using of lactobacillus with levofloxacin was better results than the other three groups.

【 授权许可】

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