Drug delivery system and in vitro release of luteolin based on magnetic nanocomposite (Fe 3 O 4 @ZIF-67)

Micro & nano letters

article

Yuqiong Shi¹  Beibei Qiu¹  Xiangrong Wu¹  Yuxuan Wang¹  Jinhua Zhu¹  Xiuhua Liu¹  Dongbao Zhao² 

[1] Henan International Joint Laboratory of Medicinal Plants Utilization, College of Chemistry and Chemical Engineering, Henan University;Center for Multi-Omics Research, School of Life Science, Henan University

关键词: drug delivery systems;    thermal analysis;    adsorption;    scanning electron microscopy;    transmission electron microscopy;    biomedical materials;    drugs;    nanocomposites;    X-ray diffraction;    nanofabrication;    Fourier transform infrared spectra;    iron compounds;    nanomedicine;    organometallic compounds;    nanomagnetics;    reaction rate constants;    magnetic hysteresis;    in vitro release;    luteolin;    magnetic nanocomposite;    facile synthesis method;    simply continuous stirring;    optimal reaction conditions;    maximum drug loading capacity;    quasisecond-order kinetic equation;    release mechanism;    LUT delivery system;    slow-release drug delivery system;    structural properties;    SEM;    TEM;    XRD;    FTIR spectra;    TGA;    adsorption kinetics;    Sigmoidal model;    vibrating sample magnetometer;    time 72.0 hour;    Fe3O4;   

DOI  :  10.1049/mnl.2019.0671

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

To extend the wide application range of luteolin (LUT), a slow-release drug delivery system is urgently needed. In this work, Fe 3 O 4 @ZIF-67 was reported as the carrier of LUT. A facile synthesis method of Fe 3 O 4 @ZIF-67 was established with simply continuous stirring. The structure and function of the nanocomposites were characterised by SEM, TEM, XRD, FTIR, VEM and TGA. Under the optimal reaction conditions, the maximum drug loading capacity of the carrier was obtained to be 308.07 µg/mg. And LUT was released about 55% from Fe 3 O 4 @ZIF-67 after 72 h. The adsorption kinetics and release kinetics of LUT were also investigated. The results showed that the relationship between time and drug loading fitted well with the quasi-second-order kinetic equation ( R 2 = 0.99) and the release mechanism followed the Sigmoidal model ( R 2 = 0.98). In short, Fe 3 O 4 @ZIF-67 could be developed as a carrier of the LUT delivery system for slow release.

【 授权许可】

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