Impact of gate material engineering on ED-TFET for improving DC/analogue-RF/linearity performances

Micro & nano letters

article

Bandi Venkata Chandan¹  Sushmitha Dasari¹  Kaushal Nigam²  Shivendra Yadav¹  Sunil Pandey¹  Dheeraj Sharma¹ 

[1] Circuit and System Design Lab, Electronics and Communication Engineering Discipline, Indian Institute of Information Technology;Circuit and System Design Lab, Electronics and Communication Engineering Discipline, Jaypee Institute of Information Technology

关键词: tunnel transistors;    field effect transistors;    work function;    nanoelectronics;    dual metal gate;    linearity performance improvement;    DMG-ED-TFET;    linearity performance metrics;    gate-to-drain capacitance;    linearity parameters;    gate electrode;    gate material engineering;    fabrication complexity;    gate work-function engineering;    DC-analogue-RF-linearity performances;    nanoscale devices;    polarity controlled electrically doped tunnel field-effect transistor;    p+ source regions;    n+ drain regions;    ATLAS device simulator;    figure of merits;    gain bandwidth product;    cut-off frequency;    third-order transconductance coefficient;    voltage 1.2 V;    voltage -1.2 V;   

DOI  :  10.1049/mnl.2018.5131

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

The bioequivalence of a single dose tablet containing 5 mg amlodipine as a test product in comparison to Norvasc® 5 mg tablet (Pfizer USA) as the reference product was studied. Both products were administered to twenty eight healthy male adult subjects applying  a fasting, single-dose, two-treatment, two-period, two-sequence, randomized crossover design with two weeks washout period between dosing. Twenty blood samples were withdrawn from each subject over 144 hours period. Amlodipine concentrations were determined in plasma by a validated HPLC-MS/MS method. From the plasma concentration-time data of each individual, the pharmacokinetic parameters; Cmax, Tmax, AUC0-t, AUC0-Â¥, Cmax/AUC0-Â¥, lZ, T0.5, MRT, Cl/F and Vd/F; were calculated applying non-compartmental analysis. The average values of the above parameters  for the test formula were 1.99 ng/ml, 8.3 hours, 82.87 ng.hr/ml, 95.23 ng.hr/ml, 0.0219 hr-1, 0.018 hr-1, 38.5 hr, 56.2 hr, 60.9 l/hr and 3483 liters, respectively. The average values of these parameter for the reference formula were 1.92 ng/ml, 7.9 hours, 76.3 ng.hr/ml, 89.31 ng.hr/ml, 0.0225hr-1, 0.019  hr-1, 36.7 hr, 59.9 hr, 69.5 l/hr, and 3983.4 liters, respectively. The pharmacokinetic parameters mentioned above were statistically analyzed by ANOVA test. Ln-transformed values of the pharmacokinetic parameters used for bioequivalence testing; Cmax, AUC0-t and AUC0-Â¥ ; were also statistically analyzed by ANOVA, 90% Confidence Interval (CI) and Schuirmann’s two one-sided t-tests. For the Tmax, parametric and nonparametric tests were applied. Based on FDA criteria on bioequivalence, the results of the above statistical tests demonstrated bioequivalence of the two products.

【 授权许可】

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