Effective design technique for improvement of electrostatics behaviour of dopingless TFET: proposal, investigation and optimisation

Micro & nano letters

article

Mohd. Aslam¹  Dheeraj Sharma¹  Deepak Soni¹  Shivendra Yadav¹  Bhagwan Ram Raad¹  Dharmendra Singh Yadav¹  Neeraj Sharma² 

[1] Electronics and Communication Engineering Discipline, PDPM-Indian Institute of Information Technology;Ramrao Adik Institute of Technology

关键词: work function;    field effect transistors;    tunnel transistors;    electron density;    tunnelling;    electrostatics;    nanoelectronics;    semiconductor junctions;    device optimisation section;    conventional structures;    effective design technique;    dopingless TFET;    rapid tunnelling junction formation;    sub-nanometre tunnel field-effect transistor;    improved electrostatics characteristics;    wide tunnelling barrier;    metal angle;    MA;    dielectric layer;    enhanced electrical behaviour;    improved electron tunnelling rate;    work-function optimisation;    electron density;    device optimisation;    length optimisation;    channel-source junction;    channel-source interface;    RF-DC parameters;    complex fabrication steps;    circuit level performance;   

DOI  :  10.1049/mnl.2018.5129

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

This study was carried out to prepare and characterize domperidone nanoparticles to enhance solubility and the release rate. Domperidone is practically insoluble in water and has low and an erratic bioavailability range from 13%-17%. The domperidone nanoparticles were prepared by solvent/antisolvent precipitation method at different polymer:drug ratios of 1:1 and 2:1 using different polymers and grades of poly vinyl pyrolidone, hydroxy propyl methyl cellulose and sodium carboxymethyl cellulose as stabilizers. The effect of polymer type, ratio of polymer:drug, solvent:antisolvent ratio, stirring rate and stirring time on the particle size, were investigated and found to have a significant (p? 0.05) effect on particle size. The best formula was obtained with lowest average particle size of 84.05. This formula was studied for compatibility by FTIR and DSC, surface morphology by FESEM and crystalline state by XRPD. Then domperidone nanoparticles were formulated into a simple capsule dosage form in order to study of the in vitro release of drug from nanoparticles in comparison raw drug and mixture of polymer:drug ratios of 2:1. The release of domperidone from best formula was highly improved with a significant (p? 0.05) increase.

【 授权许可】

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