Fabrication of folate-phytosterol-carboxymethyl cellulose nanoparticles derived from plant material as carrier of anticancer drug

Micro & nano letters

article

Ezzat Hamdy Elshazly¹  Lizhen Yu¹  Yue Zhang¹  Hui Wang¹  Kuanmin Chen¹  Song Zhang¹  Lixia Ke¹  Renmin Gong¹ 

[1] College of Life Science, Anhui Normal University;Department of Botany and Microbiology, Faculty of Science, Al Azhar University;School of pharmacy, Wannan Medical College;School of Forensic Medicine, Wannan Medical College

关键词: drug delivery systems;    nanomedicine;    tumours;    solubility;    nanoparticles;    pH;    cancer;    cellular biophysics;    nanofabrication;    self-assembly;    hydrophobicity;    folate-phytosterol-carboxymethyl cellulose nanoparticles;    plant material;    hydrophobic anticancer drugs;    hydrophobic phytosterol;    water-soluble carboxymethyl cellulose;    in vitro drug release test;    drug-loaded FPCMC NP;    doxorubicin;    model anticancer drug;   

DOI  :  10.1049/mnl.2019.0080

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

In this work, folate-phytosterol-carboxymethyl cellulose nanoparticles (FPCMC NPs) derived from plant material were fabricated and investigated as carrier of hydrophobic anticancer drugs. Firstly, hydrophobic phytosterol was grafted onto the framework of water-soluble carboxymethyl cellulose. Then folate, as tumor-targeting ligand, was coupled to the phytosterol-carboxymethyl cellulose to become self-assembled FPCMC NPs. The physicochemical properties of the fabricated FPCMC NPs were characterized. Doxorubicin (DOX) was selected as model anticancer drug that was entrapped in prepared FPCMC NPs with satisfactory loading content (7%) and loading efficiency (71.2%). The in vitro drug release test showed that the release amount of DOX from drug-loaded FPCMC NPs at pH 5.3 was much higher than that at pH 6.5 or pH 7.4. The research results indicated that the fabricated FPCMC NPs had the potential as nanocarrier of hydrophobic anticancer drugs for further experimental study.

【 授权许可】

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