Magnetic hyperthermia behaviour of Co and reduced GO nanocomposites

Micro & nano letters

article

Anahita Kakavand¹  Sayed Khatiboleslam Sadrnezhaad² 

[1]Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University

[2]Department of Materials Science and Engineering, Sharif University of Technology

关键词: graphene;    biomedical materials;    nanofabrication;    magnetic particles;    precipitation (physical chemistry);    hyperthermia;    nanoparticles;    nanocomposites;    nanomagnetics;    toxicology;    nanomedicine;    thermal analysis;    X-ray diffraction;    X-ray photoelectron spectra;    magnetometry;    cobalt;    transmission electron microscopy;    field emission scanning electron microscopy;    field emission scanning electron microscopy;    transmission electron microscopy;    X-ray photoelectron spectroscopy;    sample magnetometry;    X-ray diffraction methods;    time–temperature curves;    magnetic-field response;    biological behaviour;    3-(4;    5-dimethylthiazol-2-yl)-2;    5-diphenyltetrazolium bromide assay;    biocompatibility behaviour;    magnetic hyperthermia behaviour;    GO nanocomposites;    graphene oxide;    magnetic thermal therapy;    specific heating rates;    thermogravimetric analysis-derivative thermogravimetry;    coprecipitation;    temperature 400.0 degC;    time 4.0 hour;    Co-CO;   

DOI  :  10.1049/mnl.2019.0272

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Co-precipitation of CoCl 2 . 6H 2 O with graphene oxide (GO) and heating at 400°C for 4 h under hydrogen resulted in the construction of cobalt/reduced GO (Co/rGO) nanocomposite utilisable in magnetic thermal therapy. Field emission scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, vibrating sample magnetometry, thermogravimetric analysis/derivative thermogravimetry, and X-ray diffraction methods characterised the samples. Time–temperature curves of the samples containing 30, 50, 70, and 100 µg ml −1 Co/rGO nanoparticles (NPs) suspended in phosphate-buffered saline were determined at different specific heating rates. Magnetic-field response of Co/rGO nanocomposites was better than CoNPs and GO. The biological behaviour of the powders was investigated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Co/rGO nanocomposites showed an acceptable biocompatibility behaviour, whereas the CoNPs demonstrated toxic conduct.

【 授权许可】

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