Synthesis of hybrid AuNPs functionalised superparamagnetic NPs

Micro & nano letters

article

Deepak B. Thimiri Govinda Raj¹  Niamat Ali Khan³ 

[1] Envirotransgene® Bio-solutions Global;Biotechnology Centre for Oslo, Centre for Molecular Medicine Norway (NCMM);Laboratory of Lipid Metabolism and Cancer

关键词: gold;    nanoparticles;    magnetic particles;    superparamagnetism;    nanocomposites;    nanobiotechnology;    biomedical materials;    nanofabrication;    Au;    subcellular fractionation;    magnetic cell separation;    protein bioconjugation;    peptide bioconjugation;    gold nanoparticles;    amino end-group phospholipid functionalised superparamagnetic nanoparticles;    surface functionalisation;    biocompatible shell;    water-dispersible shell;    physical properties;    chemical properties;   

DOI  :  10.1049/mnl.2017.0574

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

In recent times, superparamagnetic nanoparticles (SPMNPs) are of tremendous interest due to its physical and chemical properties. To apply SPMNPs for biological applications, SPMNPs are surface functionalised with biocompatible and water-dispersible shell. However, most of the surface functionalisation are limited in its stability and durability. This work elaborates innovative approach for surface functionalisation of SPMNPs with gold NPs (AuNPs). Using this methodology, amino end-group phospholipid functionalised SPMNPs (SPMNP 2.0) are coupled with AuNPs as an alternative strategy to retain highly biocompatible NPs. As a future perspective, gold functionalised SPMNP 2.0 could be used for protein or peptide bioconjugation, magnetic cell separation and subcellular fractionation.

【 授权许可】

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