Design of core–shell gold-coated superparamagnetic nanoparticles as a theranostic for targeted magnetic resonance imaging and photoablation therapy

Micro & nano letters

article

Daniel Goldstein¹  Chendong Han¹  Matthew Mahan¹  Amber Doiron² 

[1] Department of Biomedical Engineering, Binghamton University;Department of Electrical and Biomedical Engineering, University of Vermont

关键词: superparamagnetism;    gold;    nanomagnetics;    cellular biophysics;    nanoparticles;    magnetic particles;    biomedical materials;    nanomedicine;    iron compounds;    surface plasmon resonance;    transmission electron microscopy;    nanofabrication;    blood vessels;    X-ray chemical analysis;    therapeutic capabilities;    superparamagnetic iron oxide nanoparticles;    gold-coated SPIO nanoparticles;    core–shell gold-coated superparamagnetic nanoparticles;    targeted magnetic resonance imaging;    photoablation therapy;    integrating diagnostic capabilities;    surface functionalisation;    surface plasmon resonance;    biocompatibility;    suspension;    energy dispersive spectroscopy;    transmission electron microscopy;    human umbilical vein endothelial cells;    darkfield microscopy;    size 8.0 nm;    size 0.5 nm;    Au-Fe3O4;   

DOI  :  10.1049/mnl.2019.0051

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

A theranostic refers to the concept of integrating diagnostic and therapeutic capabilities into a single platform. In this work, a layer of gold was reduced around superparamagnetic iron oxide (SPIO) nanoparticles to be used as a theranostic for magnetic resonance imaging and photoablation. In addition, a gold shell was included in the particle design to improve biocompatibility, stabilise nanoparticles in suspension, and allow robust surface functionalisation. Gold-coated SPIO nanoparticles of 8 nm in diameter exhibited surface plasmon resonance while also maintaining their superparamagnetic nature. Energy dispersive spectroscopy confirmed the existence of gold at the surface of the nanoparticles, the thickness of which was 0.5 nm based on transmission electron microscopy measurements. To demonstrate their potential for targeted therapies, nanoparticles were targeted to VCAM-1 on human umbilical vein endothelial cells and detected via darkfield microscopy.

【 授权许可】

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